Actively Recruiting
Aerobic Vs Neuromuscular Exercise for Knee OA
Led by Frederiksberg University Hospital · Updated on 2024-09-05
150
Participants Needed
1
Research Sites
148 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study aims to compare the effects of an education and High Intensity Interval Training program (eHIIT) with the widely used Neuromuscular Exercise and education program (NEMEX-e) on knee OA symptoms and risk factors for cardiovascular disease in people with knee OA and at least one risk factor for developement of cardiovascular disease. The main research questions the study aims to answer are: * Is the eHIIT program better than the NEMEX-e program for reducing the risk of cardiovascular disease? * Are the two programs equally good at providing improvement in knee symptoms?
CONDITIONS
Official Title
Aerobic Vs Neuromuscular Exercise for Knee OA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of tibiofemoral knee osteoarthritis according to American College of Rheumatology criteria
- Radiographic confirmation of tibiofemoral osteoarthritis based on images not older than 6 months
- Average knee pain level of 4 or higher on a 0 to 10 scale over the past week
- At least one cardiovascular risk factor: body mass index 30 or higher, hypertension (systolic 2135 or diastolic 2185 mm Hg or treated), elevated HbA1c (2130.7 mg/dL or treated), elevated triglycerides (2150 mg/dL or treated), or elevated cholesterol (LDL 254 mg/dL or treated)
You will not qualify if you...
- Contraindications to exercise (e.g., resting systolic blood pressure over 200 or diastolic over 115, acute or recurring chest pain)
- Unstable body weight in last 3 months (gain or loss outside +/- 5 kg)
- Planned weight loss during study participation
- Known current cancer
- Major cardiovascular event within last 5 years
- Insulin dependent type 1 or type 2 diabetes
- Psoriatic, rheumatoid, or gouty arthritis
- Generalized pain syndromes such as fibromyalgia
- Lumbar or cervical nerve root compression syndromes
- Scheduled surgery during study participation
- Treatment with biological medication
- Impairments preventing participation in high intensity aerobic exercise
- Current or planned participation in other health research intervention studies
- Pregnant or considering pregnancy
- Any other condition or impairment making participation unsuitable, such as large knee joint effusion, uncontrolled diabetes or hypertension, psychiatric or cognitive disorders, language barriers, or opiate dependency
AI-Screening
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Trial Site Locations
Total: 1 location
1
The Parker Institute, Frederiksberg Hospital
Copenhagen, Denmark, 2000
Actively Recruiting
Research Team
M
Marius Henriksen, PhD
CONTACT
C
Cecilie Bartholdy
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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