Actively Recruiting
Affect-based Impulsivity in Borderline Personality Disorder
Led by University of North Carolina, Chapel Hill · Updated on 2025-09-24
106
Participants Needed
1
Research Sites
44 weeks
Total Duration
On this page
Sponsors
U
University of North Carolina, Chapel Hill
Lead Sponsor
N
North Carolina Translational and Clinical Sciences Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to investigate how personality traits and neuroendocrine systems relate to decision-making patterns in individuals 18-45 years old. The main question it aims to answer is how neuroendocrine activity impacts decision-making. Participants will complete online behavioral tasks, a stress induction procedure, self-report surveys, and a cognitive assessment. During the session, psychophysiological measures will be collected, including electrocardiogram (ECG) and cardiac impedance (ICG) to monitor heart rate and blood flow, as well as electrodermal activity (EDA), blood drop samples, and saliva collection to assess nervous system activity.
CONDITIONS
Official Title
Affect-based Impulsivity in Borderline Personality Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 45 years
- Signed and dated informed consent form
- Willingness to comply with all study procedures and lifestyle considerations
- Ability to participate in all components of the study
- Ability to speak, understand, and read English
- At least 20/40 visual acuity (corrected or uncorrected)
- For BPD group: Score of 38 or higher on Personality Assessment Inventory-Borderline Scale (PAI-BOR)
- For BPD group: At least 3 BPD symptoms including affective instability per clinical interview
- For BPD group: Score of at least 80 on Reynolds Intellectual Screening Test (RIST)
- For Healthy Control group: Score of 12 or lower on PAI-BOR
- For Healthy Control group: Score below 50th percentile on World Health Organization Disability Assessment Schedule (WHODAS)
- For Healthy Control group: No current or lifetime psychiatric disorders including personality disorders as determined by diagnostic interviews
You will not qualify if you...
- Use of as needed antihypertensive agents within 12 hours prior to lab visit
- Inability to refrain from using as needed psychotropic medications for 12 hours prior to lab visit
- History of psychotic disorder, Bipolar I disorder, autism spectrum disorder, reactive attachment disorder, pervasive developmental disorder, motor disorder, head injury, mental retardation, neurological disorder, or current substance dependence
- Family history of Bipolar I disorder in a first degree relative
- Presence of cardiac pacemaker, aneurysm clip, cochlear implants, neurostimulators, or shrapnel
- Pregnancy
- History of metal fragments in eyes
- Weight of 250 lbs or more
- Claustrophobia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
Research Team
M
Michael N Hallquist, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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