Actively Recruiting
Afterload Mismatch Predictive modLE for Transcatheter Edge-to-Edge Repair (AMPLE-TEER Study)
Led by Sun Yat-sen University · Updated on 2025-06-13
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Mitral regurgitation (MR) is a common heart valve disease that can lead to heart failure. This research evaluates adult patients undergoing transcatheter mitral valve edge-to-edge repair (TEER) during hospitalization to study the occurrence of afterload mismatch (AM), a condition that limits the benefits of TEER by causing persistent heart damage and increasing mortality. The study aims to identify risk factors for AM and develop a clinical model to guide better management after TEER. The study observes adult patients receiving TEER as part of their hospital care. It follows these patients to see if they develop AM after the procedure. This observational study collects data during hospitalization and continues monitoring through an average of five years to assess long-term outcomes related to AM following TEER. Participants will be monitored for the development of afterload mismatch over the course of the study, which lasts about five years on average. Researchers will evaluate clinical factors to predict AM and use this information to build a model for guiding postoperative care. Outcome measures focus mainly on the occurrence of AM, and data collection will continue through the study completion to track patient prognosis and improve clinical decision-making.
CONDITIONS
Brief Title
Afterload Mismatch Predictive modLE for Transcatheter Edge-to-Edge Repair (AMPLE-TEER)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing transcatheter mitral valve edge-to-edge repair (TEER) during hospitalization
- Aged over 18 years
You will not qualify if you...
- Patients unable to provide written consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 years
Participants who undergo routine care are observed to assess afterload mismatch over time following their transcatheter mitral valve edge-to-edge repair (TEER).
Regular visits during hospitalization and follow-up visits over 5 years
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China
Actively Recruiting
Research Team
X
Xiaodong Zhuang
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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