Predicting Afterload Mismatch in Adults Undergoing Transcatheter Mitral Valve Edge-to-Edge Repair

What this Trial Is About

Mitral regurgitation MR is a common heart valve disease that can lead to heart failure. This research evaluates adult patients undergoing transcatheter mitral valve edge-to-edge repair TEER during hospitalization to study the occurrence of afterload mismatch AM, a condition that limits the benefits of TEER by causing persistent heart damage and increasing mortality. The study aims to identify risk factors for AM and develop a clinical model to guide better management after TEER. The study observes adult patients receiving TEER as part of their hospital care. It follows these patients to see if they develop AM after the procedure. This observational study collects data during hospitalization and continues monitoring through an average of five years to assess long-term outcomes related to AM following TEER. Participants will be monitored for the development of afterload mismatch over the course of the study, which lasts about five years on average. Researchers will evaluate clinical factors to predict AM and use this information to build a model for guiding postoperative care. Outcome measures focus mainly on the occurrence of AM, and data collection will continue through the study completion to track patient prognosis and improve clinical decision-making.

Afterload Mismatch Predictive modLE for Transcatheter Edge-to-Edge Repair (AMPLE-TEER)