Study on How Exercise Affects Insulin Resistance and Fat in Older Adults Aged 60 to 80

What this Trial Is About

Researchers are studying how aging affects insulin resistance, a key factor in type 2 diabetes and metabolic syndrome that is common in older adults. The study focuses on how fat deposits in muscles, liver, and heart relate to obesity, physical inactivity, and insulin resistance. It aims to understand whether exercise can improve fat burning capacity and reduce harmful fat metabolites, leading to better insulin resistance in sedentary obese, normal weight individuals, and masters athletes aged 60 to 80. Participants will be divided into groups based on their activity and weight sedentary obese, sedentary normal weight, and athletes who do not receive an intervention. The study involves a supervised exercise program designed to improve physical fitness and metabolic health. The intervention lasts up to 4 months and examines changes in insulin sensitivity, ectopic lipids, and oxidative capacity. During the study, participants will undergo assessments including body composition, metabolic flexibility, exercise efficiency, and physical fitness. Researchers will monitor insulin sensitivity and fat deposits in relevant tissues at the start and after 4 months. The study also tracks safety and adherence to the exercise program. Total participation time covers at least 4 months, with detailed evaluations throughout this period.

Age and Insulin Resistance