Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle.
Chiara Greggio, Pooja Jha, Sameer S Kulkarni...
https://pubmed.ncbi.nlm.nih.gov/27916530Actively Recruiting
Phase Not Applicable
Age: 60Years - 80Years
All Genders
Healthy Volunteers
ID01224886
In French AGIR Means to Get Into Action: Study of Exercise Impact on Insulin Resistance in Older Adults
Led by University of Lausanne · Updated on 2024-12-05
150
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Lausanne
Lead Sponsor
C
Centre Hospitalier Universitaire Vaudois
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying how aging affects insulin resistance, a key factor in type 2 diabetes and metabolic syndrome that is common in older adults. The study focuses on how fat deposits in muscles, liver, and heart relate to obesity, physical inactivity, and insulin resistance. It aims to understand whether exercise can improve fat burning capacity and reduce harmful fat metabolites, leading to better insulin resistance in sedentary obese, normal weight individuals, and masters athletes aged 60 to 80. Participants will be divided into groups based on their activity and weight: sedentary obese, sedentary normal weight, and athletes who do not receive an intervention. The study involves a supervised exercise program designed to improve physical fitness and metabolic health. The intervention lasts up to 4 months and examines changes in insulin sensitivity, ectopic lipids, and oxidative capacity. During the study, participants will undergo assessments including body composition, metabolic flexibility, exercise efficiency, and physical fitness. Researchers will monitor insulin sensitivity and fat deposits in relevant tissues at the start and after 4 months. The study also tracks safety and adherence to the exercise program. Total participation time covers at least 4 months, with detailed evaluations throughout this period.
CONDITIONS
Brief Title
Age and Insulin Resistance
Who Can Participate
Age: 60Years - 80Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age 60 to 80 years
- Sedentary or highly trained individuals
- Body mass index (BMI) between 18 and 40
- Non-smokers
- Normal or impaired glucose tolerance
- Willingness to comply with the study protocol
You will not qualify if you...
- Medical conditions preventing moderate exercise, including significant cardiovascular disease, peripheral vascular disease, uncontrolled hypertension, neurological or orthopedic disease
- Recent weight loss or weight gain
- Known diabetes
- Use of drugs affecting glucose homeostasis such as nicotinic acid or glucocorticoids
- Severe anemia, lipid disorders, liver or kidney disease
- Recent history of cancer
- Hypothyroidism
- Recent hormone replacement therapy
- Allergy to lidocaine or other local anesthetics
- Positive stress test
- Active alcohol or substance abuse
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Outpatient Treatment
Duration - Up to 4 months
Participants engage in a supervised exercise intervention to study its impact on insulin resistance.
Regular supervised exercise sessions during the treatment period
Trial Site Locations
Total: 2 locations
1
University of Bern
Bern, Switzerland
Active, Not Recruiting
2
UNIL and CHUV
Lausanne, Switzerland, 1005
Actively Recruiting
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Research Team
F
Francesca Amati, MD, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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Published Research Related To This Trial
Exercise efficiency relates with mitochondrial content and function in older adults.
Nicholas T Broskey, Andreas Boss, Elie-Jacques Fares...
https://pubmed.ncbi.nlm.nih.gov/26059033Skeletal muscle mitochondria in the elderly: effects of physical fitness and exercise training.
Nicholas T Broskey, Chiara Greggio, Andreas Boss...
https://pubmed.ncbi.nlm.nih.gov/24438376Skeletal muscle mitochondrial and lipid droplet content assessed with standardized grid sizes for stereology.
Nicholas T Broskey, Jean Daraspe, Bruno M Humbel...
https://pubmed.ncbi.nlm.nih.gov/23788579Evidence of systematic and proportional error in a widely used glucose oxidase analyser: impact for clinical research?
Francesca Amati, Nicholas T Broskey, Elvis A Carnero
https://pubmed.ncbi.nlm.nih.gov/23800101