Study of Aging, Geriatric Syndromes, and Clonal Hematopoiesis in Adults Aged 50 and Older

What this Trial Is About

Researchers are studying how aging and cardiovascular disease relate to genetic mutations in blood cells, independent of a persons chronological age. They use a detailed geriatric assessment that looks at health factors like other illnesses, medication use, physical and mental abilities, mood, falls, and social support. This approach helps understand aging more specifically than just by age alone. Participants are asked to complete various self-assessments and have physical tests such as cognitive tests, gait speed, grip strength, blood pressure, height, and weight at the start and every six months thereafter. Blood samples and cheek swabs are collected at the same times. Some participants undergoing hip or knee replacements may donate bone or marrow samples. Optional bone marrow biopsies may also be offered. Throughout the study, participants will be regularly assessed with questionnaires and physical measurements to monitor their health and mutation status. Researchers will track mutation rates, geriatric syndromes, cardiovascular disease, and how mutations may change following trauma over an estimated 10-year period. Participation may continue until death, with assessments every six months to gather data on health changes and risks.

Aging, Geriatric Syndromes and Clonal Hematopoiesis