Actively Recruiting
AI-Assisted MRE for Intestinal Fibrosis in Crohn's Disease
Led by Minhu Chen · Updated on 2025-08-05
234
Participants Needed
5
Research Sites
90 weeks
Total Duration
On this page
Sponsors
M
Minhu Chen
Lead Sponsor
S
Sixth Affiliated Hospital, Sun Yat-sen University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Intestinal fibrotic strictures represent a severe complication of Crohn's disease (CD), affecting over half of the patients. Despite the continuous emergence of novel medications, effective treatment options remain scarce. Endoscopy fails to identify the full-thickness fibrosis of the bowel wall, and standardized assessment for cross-sectional imaging has yet to be established. Previous studies have demonstrated that radiomics models based on computed tomography and deep learning models exhibit commendable diagnostic capability. Thus, this project seeks to conduct a prospective multicenter study, with plans to recruit 234 CD patients requiring bowel resection from five medical centers. The aim is to develop and validate a deep learning model based on magnetic resonance enterography (MRE) to accurately characterize intestinal fibrosis.
CONDITIONS
Official Title
AI-Assisted MRE for Intestinal Fibrosis in Crohn's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years old with confirmed Crohn's Disease based on ECCO guidelines
- Planning to have bowel resection due to stricture in ileum or colon
- Availability of histological specimens of resected intestinal walls matched with MRE
- Clear boundaries of the target bowel tract allowing accurate semi-automatic or fully automatic segmentation
You will not qualify if you...
- Inability to undergo MRI examination
- Difficulty obtaining suitable tissue after surgery
- Poor quality or artifact-containing MRE imaging
- Target bowel located at anastomosis (anastomotic stricture)
- Intestinal lesions occurring with other diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
The First Affiliated Hospital,Sun Yat-sen University
Guangzhou, Guangdong, China, 510080
Actively Recruiting
2
Sixth Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China
Not Yet Recruiting
3
Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University
Nanjing, Jiangsu, China
Not Yet Recruiting
4
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Huangpu, Shanghai Municipality, China
Not Yet Recruiting
5
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
M
Minhu Chen, Professor
CONTACT
R
Ren Mao, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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