Actively Recruiting
AI-Assisted Ultrasound and MRI Prediction of Pregnancy Outcomes in Placental-Related Fetal Growth Restriction: A Prospective Cohort Study by Xinhua Hospital
Led by Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Updated on 2026-03-16
300
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a prospective cohort study to better understand pregnancies affected by placental-related fetal growth restriction (FGR), focusing on those with isolated early-onset placental insufficiency and abnormal umbilical artery Doppler findings. The aim is to develop predictive models that integrate new intrauterine monitoring indicators along the fetal brain-placenta-heart axis with traditional fetal surveillance methods. This approach seeks to improve risk assessment and guide clinical care to enhance pregnancy outcomes. The study collects detailed fetal measurements every two weeks after FGR diagnosis, including fetal growth parameters such as biparietal diameter, head circumference, abdominal circumference, and femur length. Conventional Doppler ultrasound measures, like umbilical artery pulsatility index and middle cerebral artery flow, are taken regularly. Additional research assessments include placental vascular flow, fetal heart performance indices, and fetal brain development markers. A fetal brain MRI is also performed between 28 and 30 weeks of gestation. Participants will undergo ongoing monitoring during pregnancy, with repeated ultrasounds and Doppler scans at regular intervals. Researchers will track pregnancy outcomes during the entire pregnancy and up to 28 days after birth. This monitoring aims to evaluate the accuracy of the predictive models in identifying adverse perinatal and neonatal outcomes. The study duration spans from initial diagnosis through delivery and the early neonatal period, providing comprehensive data for analysis.
CONDITIONS
Brief Title
AI-Based Ultrasound Prediction of Pregnancy Outcomes in Placental-Related Fetal Growth Restriction (MVM-FGR): A Prospective Cohort Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Singleton pregnancy
- Isolated early-onset placental insufficiency-related fetal growth restriction (FGR)
- Priority given to cases with abnormal umbilical artery Doppler flow
- Pregnancy continuing with expectant management
- Age between 20 and 43 years
You will not qualify if you...
- Multiple pregnancy complicated by selective fetal growth restriction (sFGR)
- FGR caused by fetal structural anomalies, genetic abnormalities, or intrauterine infection
- Twin pregnancy with intrauterine fetal demise (IUFD) of one fetus
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - From diagnosis until delivery
Participants with placental-related fetal growth restriction undergo ultrasound assessments every 2 weeks after diagnosis to monitor fetal growth and blood flow, including fetal measurements and Doppler studies. An MRI of the fetal brain is performed once between 28 and 30 weeks of gestation.
Visits every 2 weeks after fetal growth restriction diagnosis, plus 1 MRI visit at 28-30 weeks
Trial Site Locations
Total: 1 location
1
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai, Shanghai, China
Shanghai, China, 200092
Actively Recruiting
Research Team
L
Luming Sun, Prof
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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