Actively Recruiting
AIC Genotyping Study
Led by Barts & The London NHS Trust · Updated on 2026-05-08
299
Participants Needed
1
Research Sites
61 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To quantify genetic variants in a focused DCM gene panel among AF-induced cardiomyopathy (AIC) and positive/negative controls
CONDITIONS
Official Title
AIC Genotyping Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Persistent atrial fibrillation before catheter ablation or cardioversion
- Left ventricular ejection fraction (LVEF) 40% or less during rate-controlled atrial fibrillation prior to catheter ablation or cardioversion for cases
- LVEF normalization to 55% or higher in sinus rhythm at least 3 months after catheter ablation or cardioversion with no atrial fibrillation detected outside an 8-week blanking period and no new or increased heart failure medications for cases
- LVEF 55% or higher during rate-controlled atrial fibrillation for negative controls
- Persistent LV systolic dysfunction (LVEF 40% or less) in sinus rhythm at least 3 months after catheter ablation or cardioversion with no atrial fibrillation detected outside an 8-week blanking period and no change in heart failure medications for positive controls
You will not qualify if you...
- Presence of alternative causes for left ventricular systolic dysfunction such as ischemic or non-ischemic cardiomyopathy before atrial fibrillation diagnosis, primary valve disease, or inherited cardiomyopathy
- Pregnancy during atrial fibrillation or within 12 months before onset of left ventricular systolic dysfunction
- Alcohol intake greater than 21 units per week
- Any history of cardiotoxic chemotherapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
St Bartholomew's Hospital, Barts Health NHS Trust
London, United Kingdom, EC1A 7BE
Actively Recruiting
Research Team
N
Nikhil Ahluwalia, MBBS, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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