Actively Recruiting
Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce Blood Pressure
Led by Weill Cornell Medical College in Qatar · Updated on 2025-07-20
100
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
Sponsors
W
Weill Cornell Medical College in Qatar
Lead Sponsor
H
Hamad Medical Corporation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main objective is to determine if in-home portable air cleaners provide persistent reductions in PM2.5 exposures and improvements in systolic blood pressure and biochemical parameters over 4-weeks in patients with metabolic syndrome residing in Qatar.
CONDITIONS
Official Title
Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce Blood Pressure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Non-smokers with 100% abstinence from smoking or vaping in the past year
- Age 18 years or older and less than 60 years old
- Living in a single residence (home or apartment) anywhere in Qatar
- Mild systolic hypertension with screening systolic blood pressure 130 to 159 mm Hg, either off treatment or on 2 or fewer stable blood pressure medications for at least 4 weeks
- Having at least two additional metabolic syndrome criteria: waist circumference ≥102 cm for males or ≥88 cm for females; fasting triglycerides ≥150 mg/dL or on triglyceride-lowering medication; HDL cholesterol ≤40 mg/dL for males or ≤50 mg/dL for females or on HDL-raising medication; fasting glucose ≥100 mg/dL
You will not qualify if you...
- Pregnancy (self-reported)
- Positive urine cotinine test indicating recent tobacco exposure
- Living with an active smoker who smokes indoors
- High-risk cardiovascular or kidney conditions prohibiting blood pressure above 130/80 mm Hg during the study, including coronary artery disease, prior stroke, heart failure, peripheral arterial disease, aneurysm, or stage 3 or higher kidney disease
- Any medical condition that increases risk from participation (as determined by investigators)
- Expected overnight travel away from residence during the study
- Use of HEPA filters in home air conditioners or individual HEPA filter use
- Inability to understand or sign informed consent
- Lung disease requiring oxygen therapy
- Cancer currently receiving treatment
- Screening visit blood pressure ≥160/100 mm Hg or fasting blood glucose ≥126 mg/dL with confirmed diabetes (HbA1c ≥6.5%), unless glucose is ≥126 mg/dL but HbA1c is <6.5%
- Medication changes in the past 4 weeks; stable therapy for blood pressure or cholesterol medications required for at least 10 weeks prior
- Left upper arm circumference >17 inches making blood pressure measurement inaccurate
- Acute illness or infection symptoms within 4 weeks prior to screening
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hamad Medical Corporation
Doha, Qatar
Actively Recruiting
Research Team
C
Charbel Abi Khalil, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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