What is this study trying to find out about metabolic syndrome?

This study is evaluating whether using portable air cleaners at home can reduce exposure to fine air pollution and improve blood pressure and metabolic health in people with metabolic syndrome. Researchers want to understand if these effects last over time. The study is led by Weill Cornell Medical College in Qatar and focuses on environmental influences on heart and metabolic diseases.

Who may be eligible for this metabolic syndrome clinical trial?

Adults aged 18 to under 60 years with mild systolic hypertension and metabolic syndrome may be eligible. Participants must be non-smokers living in a single residence in Qatar and able to use the air cleaners during the study. Please review eligibility criteria for more details.

Is there any cost to participate in this metabolic syndrome clinical trial?

Study-related care, including the study devices and all trial visits, is provided at no cost. Personal travel expenses may vary and are not guaranteed to be covered. Participants should plan accordingly for any travel related to study visits.

Actively Recruiting

Phase Not Applicable

Age: 18Years - 60Years

All Genders

ID05903950

Study of Portable Air Cleaners to Lower Blood Pressure in Adults with Metabolic Syndrome in Qatar

Led by Weill Cornell Medical College in Qatar · Updated on 2025-07-20

100

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating the effects of using portable air cleaners at home to reduce exposure to fine particulate air pollution PM2.5 and its impact on blood pressure and biochemical markers in adults with metabolic syndrome in Qatar. The study focuses on understanding whether lowering PM2.5 exposure can provide lasting improvements in systolic blood pressure and metabolic health over a period of four weeks. This research addresses the environmental factors contributing to chronic cardio-metabolic diseases like hypertension and diabetes, which significantly affect global health. Participants will be randomly assigned to use portable air cleaners at home for four weeks, with one group receiving devices equipped with High Efficiency Particulate Air HEPA filters and the other group receiving similar devices without HEPA filters. The trial involves a triple-masked design to compare the effects of the active and sham air cleaners. The study monitors changes during the 4-week intervention and continues assessments up to 10 weeks. During the study, participants will have their systolic blood pressure measured at weeks 4 and 10. Additional assessments include fasting blood sugar levels and insulin resistance index at the same time points. Researchers will also evaluate adherence and safety throughout the trial. The total participation involves initial screening, 4 weeks of intervention, and follow-up assessments to track any persistent changes in cardiovascular and metabolic health.

CONDITIONS

Brief Title

Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce Blood Pressure

Who Can Participate

Age: 18Years - 60Years

All Genders

Eligibility Criteria

You may qualify if you...

Non-smokers with no use of any smoking or vaping products in the past year
Age 18 years or older and less than 60 years old
Living in a single residence such as a home or apartment located anywhere in Qatar
Mild systolic hypertension with systolic blood pressure between 130 and 159 mm Hg, either off treatment or on stable treatment with 2 or fewer blood pressure medications for at least 4 weeks
Meeting at least two additional metabolic syndrome criteria: waist circumference ≥102 cm for males or ≥88 cm for females; fasting triglycerides ≥150 mg/dL or on triglyceride-lowering medication; HDL cholesterol ≤40 mg/dL for males or ≤50 mg/dL for females or on HDL-raising medication; fasting glucose ≥100 mg/dL

You will not qualify if you...

Pregnancy
Positive urine test for cotinine indicating recent tobacco use
Living with an active indoor smoker
Cardiovascular diseases such as coronary artery disease, prior stroke, heart failure, peripheral arterial disease, aneurysm
Stage 3 or higher kidney disease with eGFR less than 60 ml/min
Medical conditions placing participant at risk during the trial as determined by investigators
Planned overnight travel outside residence during the study
Use of HEPA filters in residence air conditioners or personal HEPA filter use
Inability to understand or sign informed consent
Lung diseases requiring oxygen therapy
Receiving cancer treatment
Blood pressure ≥160/100 mm Hg at screening or fasting glucose ≥126 mg/dL with confirmed diabetes (HbA1c ≥6.5%), unless HbA1c is below 6.5%
Medication changes in the past 4 weeks or unstable therapy for blood pressure or lipids in the past 10 weeks
Left upper arm circumference greater than 17 inches
Acute illness or infection symptoms within 4 weeks before screening

Research Team

Charbel Abi Khalil, MD

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Study of Portable Air Cleaners to Lower Blood Pressure in Adults with Metabolic Syndrome in Qatar

On this page

AI-Summary

What this Trial Is About

Brief Title

Who Can Participate

Eligibility Criteria

Research Team

Not the Right Trial for You?

On this page

Who Can Participate

Eligibility Criteria