Analysis of Acute Kidney Injury Risks After Controlled Low Blood Pressure Anesthesia in Orthognathic Surgery Patients Following Enhanced Recovery After Surgery ERAS Guidelines

What this Trial Is About

Researchers are investigating the effects of intentionally lowering blood pressure during general anesthesia in patients undergoing orthognathic surgery. This study aims to assess the potential risk of acute kidney injury AKI by monitoring kidney function indicators such as serum creatinine and urine analysis throughout the surgery. The goal is to identify early risk factors for AKI to help prevent postoperative kidney damage and support faster recovery following Enhanced Recovery After Surgery ERAS guidelines. Participants receive either nitroglycerin alone or nitroglycerin combined with labetalol to lower blood pressure during the operation. Throughout the surgery, their arterial blood pressure and other vital signs like cardiac output and oxygen levels are continuously monitored. The study observes these parameters during the 2 to 6 hours of surgery and tracks anesthesia drug usage. Postoperative monitoring includes the time to remove breathing tubes, discharge from recovery, and any side effects or adverse events for up to 48 hours. During the study, participants will have urine and blood tests to measure kidney function before, during, and up to 24 hours after surgery. Researchers will also track vital signs and anesthesia details closely during and after the operation. This detailed monitoring helps evaluate kidney health and overall recovery, with safety assessments continuing for two days post-surgery. The total participation duration covers the surgical period and the immediate postoperative recovery phase.

AKI Risk Factors Analysis After Intentional Hypotensive Anesthesia