Actively Recruiting
Albumin for Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Therapy -2
Led by Capital Medical University · Updated on 2026-04-15
1192
Participants Needed
12
Research Sites
101 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a prospective, multicenter, open-label, randomized controlled clinical trial. The investigators will apply albumin to the reperfusion treatment of patients with acute ischemic stroke in the anterior circulation. This study aims to verify the efficacy and safety of albumin combined with endovascular treatment in patients with anterior circulation acute ischemic stroke.
CONDITIONS
Official Title
Albumin for Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Therapy -2
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years
- Acute ischemic stroke with indication for endovascular treatment within 24 hours of onset
- Stroke in the anterior circulation with vessel occlusion in the intracranial internal carotid artery or M1/M2 segment of the middle cerebral artery
- National Institute of Health Stroke Scale (NIHSS) score of 6 or higher
- Alberta Stroke Program Early CT Score (ASPECTS) of 3 or higher
- Modified Rankin Scale (mRS) score of 4 or less before stroke onset
- Written informed consent from patient or legal representative
You will not qualify if you...
- Evidence of intracranial hemorrhage on baseline CT or MRI
- History of bleeding disorders or coagulation deficiencies
- Difficulty completing endovascular treatment due to vascular tortuosity
- Severe allergy to contrast agents not controlled by medication
- Pregnancy or breastfeeding
- Congestive heart failure episode or worsening within past 6 months
- Heart valve disease with heart failure within past 6 months
- Cardiac surgery with thoracotomy within past 6 months
- Acute myocardial infarction within past 6 months or signs upon admission
- Elevated serum troponin upon admission (>0.1 bcg/L)
- Acute arrhythmia with hemodynamic instability upon admission
- Chronic lung diseases requiring oxygen therapy
- Physical exam signs of congestive heart failure or pulmonary issues
- Severe chronic anemia (hemoglobin < 75 g/L)
- Recent or current serum creatinine >1.5 times upper limit or eGFR <60 mL/min
- Refractory hypertension (systolic >220 mmHg or diastolic >110 mmHg)
- Elevated liver enzymes (ALT or AST >1.5 times upper limit)
- History of allergy to albumin
- Severe mental disorders or dementia preventing consent or follow-up
- Expected survival less than 90 days
- Participation in other interventional clinical studies within 30 days
- Other conditions deemed unsuitable by investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 12 locations
1
Taihe County Hospital of Traditional Chinese Medicine
Fuyang, Anhui, China
Actively Recruiting
2
Si County People's Hospital
Suzhou, Anhui, China
Actively Recruiting
3
Xuanwu Hospital，Capital Medical University
Beijing, Beijing Municipality, China, 100053
Actively Recruiting
4
Shanghai General Hospital Jiujuan Hospital
Jiuquan, Gansu, China
Actively Recruiting
5
Gansu Provincial Hospital
Lanzhou, Gansu, China
Actively Recruiting
6
Jixi People's Hospital
Jixi, Heilongjiang, China
Actively Recruiting
7
Ningling County People's Hospital
Shangqiu, Henan, China
Actively Recruiting
8
The First Affiliated Hospital of Xinxiang Medical University
Weihui, Henan, China
Actively Recruiting
9
The First Affiliated Hospital of Henan University of Chinese Medicine
Zhengzhou, Henan, China
Not Yet Recruiting
10
Zhongmou County People's Hospital
Zhengzhou, Henan, China
Actively Recruiting
11
Rizhao Hospital of Traditional Chinese Medicine
Rizhao, Shandong, China
Actively Recruiting
12
Laizhou People's Hospital
Yantai, Shandong, China
Actively Recruiting
Research Team
C
Chuanjie Wu, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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