Study of How Sleeve Gastrectomy Surgery Affects Alcohol Processing, Mood, and Blood Sugar in Adults 21 to 64 Years Old

What this Trial Is About

Researchers are studying how the body processes alcohol and how alcohol affects mood and blood sugar in men and women who have undergone sleeve gastrectomy, a type of weight-loss surgery. The study aims to find out if there are differences between men and women in how alcohol is handled after this surgery, and how drinking alcohol on an empty stomach versus after a meal affects blood sugar control. The study compares participants who had sleeve gastrectomy 1 to 5 years ago with people of similar age, body composition, and drinking habits who did not have surgery. Participants will undergo two types of alcohol tests one where alcohol is given orally at a dose based on fat-free mass, either after fasting overnight or after a standard meal, and another where alcohol is administered intravenously using a controlled infusion to maintain a set blood alcohol concentration. These tests allow researchers to measure alcohol absorption, subjective effects, and blood sugar responses in different conditions. During the study, participants will have blood alcohol levels, subjective alcohol effects, and blood glucose measured from before alcohol intake up to 180 minutes afterward. Gut hormones and other peptides will also be monitored. Researchers will compare responses between men and women and between those who had surgery and those who did not. The study will last until August 2028, and participation involves scheduled visits for testing under fasting and fed states.

Alcohol After Bariatric Surgery 2