Actively Recruiting
AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure
Led by Technical University of Munich · Updated on 2025-12-26
40
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF). It is hypothesized that the combination of ablation and exercise better improves peak oxygen consumption (VO2peak) through improvement of peripheral (exercise training) and central (ablation) adaptations. Exercise intervention will contain a 12-week combined, video-based, supervised, endurance, resistance and respiratory training.
CONDITIONS
Official Title
AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed heart failure with preserved ejection fraction
- Symptomatic short-persistent atrial fibrillation diagnosed within 1 year of study inclusion
You will not qualify if you...
- Paroxysmal, long-persistent, or permanent atrial fibrillation
- Clinically unstable coronary artery disease or acute coronary syndrome
- Physical or mental inability to perform exercise testing
- Prior ablation therapy
- Precapillary pulmonary hypertension at rest
- Intracardiac shunts
- Left ventricular ejection fraction less than 50%
- High-degree valve insufficiency or stenosis greater than grade 1 at rest
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of Medicine, Division of Prevention and Sports Medicine TU Munich
Munich, Germany, 80809
Actively Recruiting
Research Team
M
Martin Halle, Professor
CONTACT
M
Manuel Rattka, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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