A Master Protocol for Precision Research in Colorectal Cancer Following Patients Over Time to Improve Treatment Outcomes

What this Trial Is About

Researchers are studying colorectal cancer CRC patients to understand the interactions between tumor and host cells and how these affect patient outcomes like recurrence and survival. This observational study aims to collect detailed clinical and molecular data from a mixed group of CRC patients to improve future treatments and support experimental trials. The study is designed as a flexible infrastructure with multiple tiers to capture the biological changes driving tumor evolution. Participants are followed longitudinally for at least five years or until death, with data and samples collected at various points during their treatment journey. Patients enter the study either before surgery or before starting systemic therapy, prioritizing those without prior metastatic treatment. The study collects diverse biological samples and clinical data, including imaging, to monitor disease progression and develop experimental models and companion diagnostics. During the study, participants will undergo regular data and sample collection such as tissue biopsies, blood draws, stool samples, and imaging tests. Researchers will track the number of patients monitored over six months and the number triaged into proof-of-concept clinical trials. The study emphasizes careful monitoring, modeling, and linking of patient data to understand tumor evolution and response to treatments over time.

ALFAOMEGA Master Observational Trial