Actively Recruiting
Algorithm-based Tailoring of Dual Antiplatelet Therapy to Improve Outcomes Following Percutaneous Coronary Interventions
Led by Insel Gruppe AG, University Hospital Bern · Updated on 2025-09-16
2788
Participants Needed
3
Research Sites
283 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The use of aspirin combined with a P2Y12 inhibitor (dual antiplatelet therapy, DAPT) represents the standard of care for patients undergoing percutaneous coronary intervention (PCI) with stent implantation. The TAILOR-DAPT trial aims to investigate the benefits of a score-based decision-making algorithm to guide DAPT duration compared to a standard-of-care DAPT duration without the use of risk scores in patients undergoing PCI.
CONDITIONS
Official Title
Algorithm-based Tailoring of Dual Antiplatelet Therapy to Improve Outcomes Following Percutaneous Coronary Interventions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- PCI with drug eluting stent (DES) implantation
- Age 18 years or older
- Ability to sign informed consent before any study-specific procedure
You will not qualify if you...
- Planned staged PCI (enrollment allowed after complete revascularization with no remaining lesions)
- Indication for oral anticoagulation
- Peri-procedural complications affecting DAPT regimen as judged by the operator
- Treatment for stent thrombosis at qualifying PCI or within 1 year prior
- Active bleeding requiring medical attention at qualifying PCI
- Hemodynamic instability (low blood pressure, catecholamine infusion, hypoperfusion, or use of ventricular assist devices)
- Life expectancy less than 1 year
- Women of childbearing potential unless permanently sterile or post-menopausal
- Planned surgery within the next 3 months
- Contraindication or allergy to aspirin or P2Y12 inhibitors (clopidogrel, ticagrelor, prasugrel)
- Participation in another drug trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
University Clinical Center of the Republic of Srpska
Banja Luka, Bosnia and Herzegovina, 78000
Actively Recruiting
2
UOC Cardiologia San Giovanni Addolorata Hospital
Roma, Italy, 00184
Actively Recruiting
3
Department of Cardiology, Bern University Hospital
Bern, Switzerland, 3010
Actively Recruiting
Research Team
L
Lorenz Räber, MD, PhD
CONTACT
M
Miklos Rohla, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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