Clinical Study on Sub-phenotyping Acute Lung Injury and Acute Respiratory Distress Syndrome with Organ Injury Using Clinical and Biological Data for Personalized Treatment

What this Trial Is About

Researchers are investigating acute lung injury and acute respiratory distress syndrome ARDS, serious critical illnesses with high mortality rates of 45% to 50%. The study aims to understand the differences among patients with these conditions by creating a clinical classification system for lung and other organ injuries. This work hopes to enable personalized treatments and improve patient outcomes by analyzing clinical, physiological, and biological data. The study will collect clinical information and biological samples nationwide from patients diagnosed with ARDS. Peripheral blood samples will be taken at five specific times after ICU admission, and bronchoalveolar lavage fluid will be collected within 24 hours of ICU admission if the patient meets ARDS criteria. Mathematical and machine learning models will be used to develop and validate classification systems, including a bedside decision tool to guide precise diagnosis and treatment. Participants will contribute data and samples while in the ICU, with follow-up monitoring of outcomes such as ICU mortality up to 12 weeks, hospital mortality up to 24 weeks, time without mechanical ventilation 28 days, ICU and hospital length of stay, and mortality one year after discharge. The study seeks to build a comprehensive database and biobank to support future research and improve care for ARDS patients.

ALI/ARDS Clinical Sub-phenotyping Study