Actively Recruiting
All-extremity Exercise During Breast Cancer Chemotherapy
Led by University of Florida · Updated on 2025-10-01
68
Participants Needed
1
Research Sites
147 weeks
Total Duration
On this page
Sponsors
U
University of Florida
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Currently, there are 3.5 million breast cancer survivors in the United States and this number is expected to increase dramatically. The proposed research will examine whether a novel exercise intervention for breast cancer patients who are undergoing chemotherapy protects against cardiovascular dysfunction. Findings may have implications for cardiovascular disease prevention in this population.
CONDITIONS
Official Title
All-extremity Exercise During Breast Cancer Chemotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Active diagnosis of primary invasive non-metastatic breast cancer, stages I-III
- Female
- 18 to 85 years of age
- Scheduled to initiate neoadjuvant or adjuvant chemotherapy (anthracycline, alkylating agent and/or taxane)
- Absence of contraindications to exercise
- Study clinician approval
- Able to give consent
- Informed consent obtained from the subject and documentation of subject agreement to comply with study-related process
You will not qualify if you...
- Do not meet inclusion criteria
- Receiving targeted therapies (CDK4/6 or PARP inhibitors)
- Receiving radiation therapy concurrent with chemotherapy
- Lymphedema stage 64 2 prior to study enrollment
- Any relevant cardiovascular diseases (stroke, heart failure, myocardial ischemia during maximal graded exercise test, myocardial infarction, angina pectoris, coronary artery bypass surgery or angioplasty or coronary stent)
- Current participation in other experimental interventions that may confound interpretation of study findings (e.g., dietary intervention for weight loss)
AI-Screening
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Trial Site Locations
Total: 1 location
1
Integrative Cardiovasculal Physiology Laboratory, University of Florida
Gainesville, Florida, United States, 32611
Actively Recruiting
Research Team
D
Demetra Christou, PhD
CONTACT
E
Eileen Handberg
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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