Actively Recruiting
Natural History Study for Genetic Diseases of Allergic Inflammation and Immune Dysregulation
Led by Columbia University · Updated on 2026-02-04
10000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying individuals of all ages with suspected or known inherited genetic diseases related to allergic inflammation and immune dysregulation. This research aims to better understand genetic and immune system factors involved in conditions such as atopic dermatitis, asthma, autoimmune diseases, anaphylaxis, and immunodeficiency. The study includes both affected patients and their family members to explore the underlying causes and mechanisms of these disorders. Participants include patients and their blood relatives who may have disorders affecting allergic inflammation or immune system regulation. The study involves collecting various biological samples such as blood, saliva, hair, fingernail clippings, cord blood, bone marrow, tissue biopsies, and buccal swabs. Researchers may also obtain outside medical records and conduct patient evaluations to support laboratory research into genetic and immunopathogenic factors. During the study, participants provide consent for sample collection and storage for future immune system research. Researchers will analyze these samples alongside clinical data to identify susceptibility traits related to these diseases over a period of up to one year. The study may involve ongoing monitoring, review of medical histories, and correlating clinical findings with laboratory results to improve diagnosis and management of allergic and immune dysregulatory disorders.
CONDITIONS
Brief Title
Allergy and Immunology Natural History Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects aged from birth to 99 years with known or suspected inherited disorders of allergic inflammation, mast cell homeostasis or activation, or immune dysregulation
- Blood relatives of enrolled subjects are eligible
- No discrimination based on age, gender, race, or disability
- Subjects or guardians must be willing and able to give informed consent
- Subjects must agree to have their blood stored for future immune system research
You will not qualify if you...
- Presence of an acquired immune system abnormality such as cytotoxic chemotherapy or malignancy that may interfere with evaluation, as determined by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 year
Participants undergo assessments to evaluate inherited disorders of allergic inflammation, mast cell homeostasis or activation, and immune dysregulation.
Visits as needed for evaluations
Duration - Up to 1 year
Participants and their blood relatives are observed to understand the genetic and immunologic basis of allergic inflammation and immune dysregulation over time.
Periodic visits depending on individual assessment
Trial Site Locations
Total: 1 location
1
Columbia University Irving Medical Center / NewYork-Presbyterian Hospital
New York, New York, United States, 10032
Actively Recruiting
Research Team
J
Joshua D. Milner, MD
Y
Yannett Franklin
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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