Study of Genetic Allergic Inflammation and Immune Dysregulation in Patients and Their Families

What this Trial Is About

Researchers are studying individuals of all ages with suspected or known inherited genetic diseases related to allergic inflammation and immune dysregulation. This research aims to better understand genetic and immune system factors involved in conditions such as atopic dermatitis, asthma, autoimmune diseases, anaphylaxis, and immunodeficiency. The study includes both affected patients and their family members to explore the underlying causes and mechanisms of these disorders. Participants include patients and their blood relatives who may have disorders affecting allergic inflammation or immune system regulation. The study involves collecting various biological samples such as blood, saliva, hair, fingernail clippings, cord blood, bone marrow, tissue biopsies, and buccal swabs. Researchers may also obtain outside medical records and conduct patient evaluations to support laboratory research into genetic and immunopathogenic factors. During the study, participants provide consent for sample collection and storage for future immune system research. Researchers will analyze these samples alongside clinical data to identify susceptibility traits related to these diseases over a period of up to one year. The study may involve ongoing monitoring, review of medical histories, and correlating clinical findings with laboratory results to improve diagnosis and management of allergic and immune dysregulatory disorders.

Allergy and Immunology Natural History Study