Actively Recruiting
Allo HSCT for High Risk Hemoglobinopathies
Led by Masonic Cancer Center, University of Minnesota · Updated on 2026-03-12
62
Participants Needed
1
Research Sites
393 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A single center, open label, interventional, phase II trial for donor transplant for high risk hemoglobinopathies and other red cell transfusion dependent disorders utilizing allogeneic hematopoietic stem cell transplantation (HSCT) regimens.
CONDITIONS
Official Title
Allo HSCT for High Risk Hemoglobinopathies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of sickle cell disease (SCD)
- SCD patients with a fully matched sibling donor regardless of symptom severity
- Transfusion dependent alpha- or beta-thalassemia
- Diagnosis of Diamond Blackfan anemia
- Other non-malignant hematologic disorders
- Karnofsky performance score of 60% or higher or Lansky play score of 60 or higher
- Patients with lower performance scores may be considered by study team evaluation
- Sexually active persons of childbearing potential or those with partners of childbearing potential must agree to use highly effective contraception during treatment and for at least 4 months after transplant
You will not qualify if you...
- Pregnant, breastfeeding, or intending to become pregnant during the study
- Persons of childbearing potential must have a negative pregnancy test within 7 days before starting treatment
- HIV positive status
- Active, uncontrolled infection; stable or improving infection after 1 week of appropriate therapy (4 weeks for fungal infections) allowed
- Known allergy to any study components
- Psychiatric illness or social situations limiting compliance with study requirements
- Other illnesses or medical issues judged by the investigator to exclude patient from the study
AI-Screening
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Trial Site Locations
Total: 1 location
1
Masonic Cancer Center
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
A
Ashish Gupta, MBBS, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
4
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