Actively Recruiting
AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion
Led by Mitchell Cairo · Updated on 2025-08-08
20
Participants Needed
1
Research Sites
352 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Children, adolescents, and young adults with malignant and non-malignant conditionsundergoing an allogeneic stem cell transplantation (AlloSCT) will have the stem cells selected utilizing α/β CD3+/CD19+ cell depletion. All other treatment is standard of care.
CONDITIONS
Official Title
AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with high-risk acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), high-risk myelodysplastic syndrome (MDS), Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), bone marrow failure syndromes including Kostmann syndrome, Diamond-Blackfan anemia, or amegakaryocytic thrombocytopenia
- Diagnosed with sickle cell disease including homozygous hemoglobin S disease or related variants
- Age between 0 and 30 years
- Adequate organ function
- Specific disease status criteria including remission stages or induction failure as detailed in the protocol
You will not qualify if you...
- Female participants who are pregnant or breastfeeding
- Presence of uncontrolled infection at study entry
- Karnofsky or Lansky performance score below 60
- Demonstrated non-compliance with medical care
- Received allogeneic hematopoietic stem cell transplant within 6 months unless as a boost
- Active graft-versus-host disease below Grade 2
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
New York Medical College
Valhalla, New York, United States, 10595
Actively Recruiting
Research Team
M
Mitchell S Cairo, MD
CONTACT
L
Lauren Harrison, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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