Actively Recruiting
Alpha-1 Blockade for Alcohol Use Disorder (AUD)
Led by Brown University · Updated on 2026-03-20
184
Participants Needed
1
Research Sites
349 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this research is to replicate findings previously conducted in a pilot trial and to understand, mechanistically, the role of stress in the development of AUD pharmacotherapies that target noradrenergic blockade.
CONDITIONS
Official Title
Alpha-1 Blockade for Alcohol Use Disorder (AUD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female, 18 years of age or older
- Meet the DSM-5 criteria for Alcohol Use Disorder
- Desire to reduce or quit alcohol drinking
- Breath alcohol (BrAC) = 0.00 at each visit
- In good health as confirmed by medical history, physical examination, and lab tests
- Willing to follow study procedures
- Able to understand informed consent and questionnaires in English at an 8th grade level
You will not qualify if you...
- Women who are breastfeeding or have a positive urine pregnancy test
- Creatinine clearance (CrCl) less than 60 mL/min
- Suicide attempt in the last three months
- Current diagnosis of any substance disorder other than nicotine
- Current use of medications that may interact with doxazosin or yohimbine
- History of allergy to any alpha receptor blockers
- Clinical Institute Withdrawal Assessment for Alcohol revised (CIWA-Ar) score 8 or higher
- Treatment with disulfiram, naltrexone, acamprosate, or topiramate within 1 month prior to screening
- Treatment with any alpha-blocker
- History of cardiac heart failure
- Baseline hypotension with blood pressure lower than 90/60 mmHg
- Use of phosphodiesterase inhibitors for erectile dysfunction
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Brown University
Providence, Rhode Island, United States, 20923
Actively Recruiting
Research Team
Z
Zoe L Brown, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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