Actively Recruiting
Alpha-Ketoglutarate and Abdominal Aortic Aneurysm Progression and Rupture
Led by RenJi Hospital · Updated on 2021-02-21
300
Participants Needed
1
Research Sites
308 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this project is to define whether nutritional supplement (oral administration with alpha-ketoglutarate) capable of filling-up the citric acid cycle (anaplerotic therapy) can improve outcomes in patients with an abdominal aortic aneurysm of 39-49 mm in diameter on ultrasound imaging. Alpha-ketoglutarate is commonly used as a nutritional supplement specially by athletes to increase muscle strength. They can be mixed with formula or other foods. Subjects will be followed for up to 5 years.
CONDITIONS
Official Title
Alpha-Ketoglutarate and Abdominal Aortic Aneurysm Progression and Rupture
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of an infrarenal AAA with a maximum diameter of 39-49 mm;
- Han nationality;
- Between 50 years or more, no gender limit;
- No mental illness;
- No history of supplement allergy or supplement allergy;
- Subjects voluntarily participate in this study, sign an informed consent form, have good compliance, and cooperate with follow-up.
You will not qualify if you...
- Previous infrarenal aortic surgery;
- Planned major surgery;
- Known aortic dissection;
- Have received any other clinical trial treatment within 1 year;
- Systemic treatment with corticosteroids or other systemic immunomodulatory therapy;
- Severe infections, including but not limited to infections requiring hospitalization, bacteremia, severe pneumonia, etc.;
- Known or suspected inherited connective tissue disorder;
- Calculated creatinine clearance of less than 30 ml/min;
- Known significant liver disease;
- Known human immunodeficiency virus infection at the time of screening；
- Serious concomitant illness associated with life expectancy of less than 2 years；
- Any other significant and unstable condition that could limit compliance with the trial protocol.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Cardiology, Ren Ji Hospital
Shanghai, China
Actively Recruiting
Research Team
J
Jun Pu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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