Actively Recruiting
Alpha-Lipoic Acid in Mitigating Cisplatin-Induced Nephrotoxicity
Led by Minia University · Updated on 2026-05-04
50
Participants Needed
1
Research Sites
64 weeks
Total Duration
On this page
Sponsors
M
Minia University
Lead Sponsor
M
Minia University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
To assess the nephroprotective efficacy of Alpha-Lipoic Acid in preventing cisplatin-induced nephrotoxicity in oncology patients by monitoring renal function changes
CONDITIONS
Official Title
Alpha-Lipoic Acid in Mitigating Cisplatin-Induced Nephrotoxicity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Histologically confirmed solid malignancy
- Planned treatment with cisplatin starting at 60 mg/m2 per cycle (21-28 days or fractionated)
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Baseline serum creatinine within normal range or estimated glomerular filtration rate (eGFR) 8 mL/min/1.73 m2
- Ability to provide informed consent
You will not qualify if you...
- Pre-existing renal impairment (eGFR < 60 mL/min/1.73 m2 or serum creatinine > 1.5 times upper limit of normal)
- Use of nephrotoxic drugs that cannot be stopped (e.g., aminoglycosides, amphotericin B, high dose NSAIDs)
- Uncontrolled hypertension, decompensated heart failure, or severe hepatic impairment
- Known allergy or intolerance to Alpha-Lipoic Acid
- Pregnancy or lactation
- Participation in another interventional clinical trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Minia University Hospital
Minya, Minya Governorate, Egypt, 61111
Actively Recruiting
Research Team
A
Asmaa Mohammed
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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