Actively Recruiting
Alpha Lipoic Acid in Ulcerative Colitis
Led by Tanta University · Updated on 2025-02-06
60
Participants Needed
1
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims at evaluating the efficacy and safety of alpha-lipoic acid as adjuvant therapy to mesalamine in patients with mild to moderate ulcerative colitis due to its effect as anti-oxidant and anti-inflammatory drug which can help to improve disease.
CONDITIONS
Official Title
Alpha Lipoic Acid in Ulcerative Colitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age ≥18 years old
- Male or female sex
- Newly diagnosed with active mild to moderate ulcerative colitis according to American College of Gastroenterology Clinical Guideline
- Currently treated with 5-aminosalisylic acid (mesalamine)
You will not qualify if you...
- Severe ulcerative colitis
- Colorectal cancer
- Use of rectal or systemic steroids
- Use of immunosuppressants or biological therapies
- Previous failure with sulphasalazine treatment
- Known allergy to study medications
- History of complete or partial colectomy
- Significant liver disease including fibrosis, cirrhosis, NASH, NAFLD
- Other inflammatory diseases
- Thyroid diseases
- Arrhythmia, ischemic heart disease, or heart failure
- Diabetes
- Use of antioxidant supplements (vitamin A, C, E), selenium, co-enzyme Q
- Use of amlodipine, levothyroxine, low strength aspirin, warfarin, atorvastatin, insulin, oral hypoglycemic, or chemotherapy due to drug interactions
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Tanat university hospital
Tanta, Egypt
Actively Recruiting
Research Team
A
Ahmed Farouk
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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