Study of Alpha-synuclein RT-QuIC and Early Neurologic Signs in Adults Aged 55 to 75 With Idiopathic Olfactory Dysfunction

What this Trial Is About

Researchers are investigating early warning signs and biomarkers for dementia with Lewy bodies DLB, a common cause of dementia linked to the buildup of misfolded alpha-synuclein protein in the brain. The study focuses on people with idiopathic olfactory dysfunctionloss or reduction of smell without known causeto better understand symptom progression and improve early diagnosis, potentially aiding future treatments. Participants include people with and without olfactory dysfunction. The study uses Real-Time Quaking-Induced Conversion RT-QuIC, a laboratory technique that detects misfolded alpha-synuclein, to assess samples from participants. It involves an exploratory cross-sectional case-control design and a long-term follow-up using Danish health registries to track diagnoses of Parkinsons disease or dementia. During the study, participants undergo smell tests, motor function exams, cognitive assessments, and evaluations of other symptoms related to Parkinsons disease and DLB at regular intervals over 24 months and longer. Researchers monitor the presence of misfolded alpha-synuclein and track diagnoses over up to 8 years. This observational study helps identify early signs and disease progression markers while participants continue their usual care.

Alpha-synuclein Rt-quic and Neurologic Symptoms in Persons With idiOpathic anosMiA