Actively Recruiting
ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of Vital Organs in ALF or ACLF
Led by Institute for Clinical and Experimental Medicine · Updated on 2026-01-09
25
Participants Needed
1
Research Sites
143 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The artificial liver support system (ALSS) in patients with acute on chronic liver failure - the use of combined molecular adsorption system with double plasma (DPMAS) and therapeutic plasma exchange (TPE), its effect on primary coagulation, inflammation and the function of vital organs.
CONDITIONS
Official Title
ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of Vital Organs in ALF or ACLF
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient, age 18 years
- Expressed consent to the inclusion
- Patient hospitalized on ICU with ALF or ACLF diagnosis
- Recently meeting the inclusion to liver transplantation
- Present on a waiting list to liver transplant
- Unsuitable for inclusion to liver transplantation - indicated for support therapy only, but not indented to palliative care
You will not qualify if you...
- Disagreement with the study
- Infaust prognosis with expected survival less than 24 hours
- Physiologically/biologically very advanced stage patients condition, severe lung disease (Gold criteria 3 or 4), heart failure (functional class NYHA III or IV) or neurological disease, as well as ACLF-3
- Advanced oncological disease (expected life expectancy below 6 months)
- Severe degree of Frailty syndrome in secondary severe sarcopenia (muscle and malnutrition) or reduced performance state according
AI-Screening
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Trial Site Locations
Total: 1 location
1
Institute for Clinical and Experimental Medicine (IKEM)
Prague, Czechia, 14200
Actively Recruiting
Research Team
P
Petr Piza, MD, MHA
CONTACT
E
Eva Kieslichova, ass. prof., MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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