Actively Recruiting
Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion
Led by M.D. Anderson Cancer Center · Updated on 2025-12-26
30
Participants Needed
1
Research Sites
180 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study investigates whether alteplase can help to improve pleural fluid drainage and dyspnea (breathlessness) in patients with non-draining malignant pleural effusion. Alteplase helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. Alteplase may help to control symptoms of breathlessness.
CONDITIONS
Official Title
Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Referral to pulmonary services for inability to drain fully via indwelling pleural catheter (IPC)
- Presence of a symptomatic septated pleural effusion
- Moderate to large pleural effusion based on chest radiograph, CT scan, or ultrasound criteria
- Age over 18 years
- Borg breathlessness score of 3 or higher
- No blockage of IPC confirmed by saline flush
- Presence of septated effusion confirmed by ultrasound and chest CT
You will not qualify if you...
- Unable to provide informed consent
- Disease or condition that prevents safe study completion, including uncorrectable coagulopathy and active bleeding
- Known allergic reaction to thrombolytic medications
- Pleural effusion smaller than expected on bedside ultrasound
- No septations or loculations seen on bedside ultrasound
- Patient has no symptoms
- Blocked IPC as determined by saline flush
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
H
Horiana Grosu, M D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here