Actively Recruiting
Alteration of the Immune Microenvironment in Basal Cell Carcinoma Following Photodynamic Therapy
Led by Case Comprehensive Cancer Center · Updated on 2025-11-26
28
Participants Needed
1
Research Sites
311 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to better understand the immune response to basal cell carcinoma (BCC) treated with Photodynamic Therapy (PDT) in order to develop new methods of treating BCC. Previous research suggests that PDT alters the immune response, possibly in a way that could promote better tumor clearance when combined with other treatments. Overall, participation in this study will help the study team better understand the anti-tumor immune response when BCC is treated with PDT.
CONDITIONS
Official Title
Alteration of the Immune Microenvironment in Basal Cell Carcinoma Following Photodynamic Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults scheduled to undergo Mohs surgery within the Dermatologic Surgery unit of the Department of Dermatology, Cleveland Clinic
- Must have at least one BCC tumor eligible for removal by surgical excision
- Men and women of any ethnic group are eligible
- Must provide informed consent to participate
You will not qualify if you...
- Pregnant or breastfeeding
- Currently being treated for other cancers with medical or radiation therapy
- Known hypersensitivity to 5-aminolevulinic acid (ALA)
- History of a photosensitivity disease, e.g.,porphyria cutanea tarda
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Cleveland Clinic, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
E
Edward V Maytin, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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