Study of Translational Process of Relationship Between Intestinal Microbiota of Dysbiosis and the Psychic Symptoms of Anorexia Nervosa (Eating Disorders and Anxio-depression Disorders)

What this Trial Is About

Researchers are investigating how changes in the intestinal microbiota, including disruptions in its balance and increased gut permeability, relate to psychic symptoms in people with anorexia nervosa (AN), such as food restriction intensity, anxiety, and depression. This observational study aims to compare the gut microbiota and host environment interactions between patients with malnutrition from AN and healthy individuals. The goal is to understand not only the genetic makeup of the microbiota but also its potential functions and how these relate to symptoms of AN. The study involves two groups: hospitalized anorexia patients with a body mass index (BMI) under 15, and healthy volunteers aged 18 or older with a BMI between 18.5 and 25. Researchers will collect stool and blood samples to analyze the microbiota using DNA sequencing and metagenomic methods. They will also assess intestinal permeability, inflammation, immunity changes, and other biological markers to explore the relationship between the gut environment and psychic symptoms. Participants will undergo evaluations at baseline, including assessments of eating disorders, anxiety, depression, physical exercise, and various biological and metabolic parameters. Researchers will also measure gut microbiota diversity, body composition, liver function, energy expenditure, and other health indicators. These comprehensive assessments aim to clarify how alterations in gut microbiota relate to AN symptoms and overall health. The study is expected to continue until October 2026.

Alteration of Symbiosis Intestinal Microbiota on Patients With Anorexia Nervosa