Actively Recruiting
Alterations in Mast Cell and Macrophage Infiltration, as Well as Micro Vessel Density
Led by General Committee of Teaching Hospitals and Institutes, Egypt · Updated on 2026-04-29
100
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Obesity is a global health problem that has reached epidemic proportions, affecting more than one billion people worldwide and significantly increasing the risk of multiple comorbidities, including type 2 diabetes, cardiovascular diseases, and cancer (World Health Organization, 2024). Increasing evidence suggests that chronic low-grade inflammation associated with obesity plays a critical role in the development of obesity-related malignancies, including gastric cancer. Adipose tissue dysfunction in obesity leads to the recruitment and activation of various immune cells, such as macrophages and mast cells, which contribute to a pro-inflammatory microenvironment through the release of cytokines, growth factors, and angiogenic mediators.
CONDITIONS
Official Title
Alterations in Mast Cell and Macrophage Infiltration, as Well as Micro Vessel Density
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients undergoing bariatric surgery (laparoscopic sleeve gastrectomy)
- Body mass index (BMI) greater than 35 kg/m²
- Completion of preoperative evaluation including blood tests and multidisciplinary assessment (nutritionist, psychiatrist, endocrinologist, radiologist, anesthesiologist, and surgeon)
You will not qualify if you...
- Secondary causes of obesity such as Cushing's syndrome or polycystic ovary syndrome (PCOS)
- Malignant gastric conditions or previous gastric surgery
- Systemic inflammatory diseases, autoimmune disorders, or chronic infections affecting immune cell infiltration
- Incomplete clinical data or poor-quality tissue samples
- Use of anti-inflammatory, immunosuppressive, or corticosteroid therapy within the last 3 months before sampling
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The surgical department of Medical Research Institute Hospital, Alexandria University
Alexandria, Alexandria Governorate, Egypt, 21531
Actively Recruiting
Research Team
M
Mohamed H Ashour, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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