Actively Recruiting
Abnormal Neural Pain Empathic Processing in Adolescents With Non-suicidal Self-Injury
Led by University of Electronic Science and Technology of China · Updated on 2024-04-11
80
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating altered neural pain empathic processing in adolescents with nonsuicidal self-injury (NSSI), which means deliberately harming oneself without suicidal intent. This condition is a growing global public health concern, especially among adolescents who often face emotional and interpersonal challenges. The study aims to compare brain activity related to pain empathy between adolescents with NSSI and healthy controls to understand differences in how they process others' physical and emotional pain. The study will recruit two groups: 40 adolescents with NSSI and 40 healthy controls. Participants will undergo functional magnetic resonance imaging (fMRI) to measure brain responses to stimuli depicting physical pain (injury to limbs) and affective pain (faces showing pain), along with matching control images. This imaging will focus on blood oxygenation level-dependent (BOLD) signals to assess neural activity over about 8 minutes. Participants aged 15 to 18 years will be involved, with specific requirements such as right-handedness and normal or corrected vision. During the study, brain activity related to pain empathy will be closely monitored using fMRI scans. Researchers will analyze differences in brain regions linked to empathy and emotional processing. The study is observational and includes healthy volunteers, with participant involvement lasting the duration of the imaging assessments.
CONDITIONS
Brief Title
Altered Neural Pain Empathic Reactivity in NSSI Adolescents
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 15 to 18 years
- Right-handed
- Normal or corrected normal vision
- Meet DSM-5 frequency criteria with nonsuicidal self-injury behaviors at least 5 days in the past year
You will not qualify if you...
- Diagnosis of borderline personality disorder, major depressive disorder, or other psychiatric disorders
- High suicidal risk
- Recent use of medications affecting neural activity
- Received or currently receiving Dialectical Behavior Therapy (DBT) or other emotional treatments within the past 6 months
- Contraindications to MRI scanning such as metal implants or claustrophobia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - About 8 minutes
Participants undergo neural activity assessment using BOLD fMRI to evaluate pain empathic processing.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China
Chengdu, Sichuan, China
Actively Recruiting
Research Team
B
Benjamin Becker
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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