Actively Recruiting
Altered Neural Pain Empathic Reactivity in NSSI Adolescents
Led by University of Electronic Science and Technology of China · Updated on 2024-04-11
80
Participants Needed
1
Research Sites
186 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Nonsuicidal self-injury (NSSI) is defined as direct, deliberate bodily harm without suicidal intention. In recent years, growing evidence suggests that NSSI has become a worldwide public health issue. People with NSSI behaviors, especially adolescents, commonly exhibit emotion-related and interpersonal problems. Pain empathy represents an essential basal domain of socio-emotional processing and refers to the ability to empathize, connect and share with others' pain. However, altered empathic processing has not been systematically examined in adolescents with NSSI. To this end, the current functional magnetic resonance imaging (fMRI) study will recruit one group of NSSI adolescents (n=40) and one healthy control (HC) group (n=40), to compare their neural activity regarding pain empathy processing, which is measured by blood oxygenation level-dependent (BOLD) fMRI. The investigators included conditions of physical pain empathy (stimuli depicting noxious stimulation to the limbs) and affective pain empathy (stimuli depicting faces expressing pain) as well as corresponding control stimuli. The investigators hypothesize that compared to HC, NSSI adolescents show increased empathic reactivity to physical pain stimuli in salience and arousal related brain regions but decreased empathic reactivity to affective pain empathic stimuli.
CONDITIONS
Official Title
Altered Neural Pain Empathic Reactivity in NSSI Adolescents
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 15 to 18 years
- Right-handed
- Normal or corrected normal visual acuity
- Meet DSM-5 criteria with 5 or more days of nonsuicidal self-injury behaviors in the past year
You will not qualify if you...
- Diagnosis of borderline personality disorder, major depressive disorder, or other psychiatric disorders
- High suicidal risk
- Recent use of medications that can affect neural activity
- Received or currently receiving Dialectical Behavior Therapy or other treatments for emotional problems within the past 6 months
- Contraindications to MRI scanning such as metal implants or claustrophobia
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China
Chengdu, Sichuan, China
Actively Recruiting
Research Team
B
Benjamin Becker
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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