Actively Recruiting
Alternate Day Fasting After Surgery for Patients Undergoing Chemotherapy
Led by Northwestern University · Updated on 2026-03-24
30
Participants Needed
1
Research Sites
145 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Endometrial cancer is the most common gynecologic cancer and ovarian cancer is the most lethal. The management of both advanced cancers is a combination of chemotherapy and surgery. Standard of care chemotherapeutic treatment for uterine and ovarian cancers is toxic and severely disruptive to the patient's quality of life with the potential for devastating short and long-term side effects. The role of fasting and ketogenic diets has been evaluated in a mixed cancer population and previously shown to be safe. There is no data specifically addressing the impact of a fasting diet regimen on side effects of chemotherapy during treatment for ovarian and endometrial cancers in the front-line setting. The information gathered from this study will inform future trials about the role of time-restricted eating and its impact on side-effects associated with chemotherapy as well as its role in improvement of quality of life for women afflicted with these debilitating diseases.
CONDITIONS
Official Title
Alternate Day Fasting After Surgery for Patients Undergoing Chemotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female aged 18 years or older
- Confirmed or highly suspected endometrial, ovarian, fallopian tube, or primary peritoneal cancer
- Scheduled to undergo adjuvant chemotherapy after hysterectomy as determined by the treating physician
- Fluent in spoken and written English
- Owns a smartphone
- Has internet access to complete surveys
- ECOG performance status of 0 or 1
- Willing to sign informed consent form
You will not qualify if you...
- Not planning to receive chemotherapy at Northwestern Medicine
- Engaged in shift work including night or third shift
- Body mass index (BMI) of 50 or higher or diagnosed with an eating disorder
- Taking medications for blood glucose regulation (e.g. insulin) or requiring therapeutic doses of anticoagulants
- Diagnosed with medication-dependent diabetes, recent heart attack, stroke, pulmonary embolism, renal failure, or any condition preventing tolerance of short-term fasting
- Taking medications affected by fasting that require monitoring (e.g. for hypertension, electrolyte abnormalities, migraines)
- Oncologist has not cleared participation
- Unable or unwilling to follow the diet regimen or participate in ketone measurements
- ECOG performance status greater than 1
- Received systemic therapy for any malignancy in the past 2 years
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Northwestern Memorial Hospital
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
A
Anne Grace, PhD
CONTACT
J
Juan Avitia, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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