Actively Recruiting
Alternative Physical Activity Strategies for Breast Cancer Survivors
Led by University of Toronto · Updated on 2025-12-02
24
Participants Needed
1
Research Sites
88 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary aim of this study is to compare the acute glycemic effects of two novel, alternative physical activity (PA) strategies (dispersed post-meal PA, PA snacks) to a no PA condition and to exercise sessions representing the PA guidelines (standard 30-minute walking bout performed under fasting and under postprandial conditions and a standard 30-minute resistance training session) among sedentary breast cancer survivors who are currently receiving hormone therapies and age- and BMI-matched postmenopausal women without a history of cancer. The secondary aim is to determine whether the alternative PA strategies are acceptable and feasible in the free-living setting. An exploratory aim is to determine whether the outcomes differ between women with and without a history of breast cancer and use of aromatase inhibitors. The investigators hypothesize that: 1. Dispersed PA and PA snacks will result in greater reductions in 24-hour glucose and postprandial glucose compared to the no-PA baseline and similar reductions to a standard 30-minute bouts of walking; 2. The alternative PA strategies will be more feasible and have greater acceptability by cancer survivors compared to the standard 30-minute bout of walking or resistance training; and 3. The different PA strategies will have similar effects on glycemic outcomes for both breast cancer survivors and cancer-free controls. The resistance exercise session is an exploratory trial as the effects of it on acute glycemic control are understudied.
CONDITIONS
Official Title
Alternative Physical Activity Strategies for Breast Cancer Survivors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Postmenopausal biological females diagnosed with stage I, II, or III breast cancer and currently using aromatase inhibitors for at least 3 months prior to start of study participation
- Body mass index equal to or greater than 25 kg/m^2
- Self-report consuming three main meals daily
- Self-report as being sedentary (less than 30 minutes/week of moderate-to-vigorous aerobic physical activity and less than twice/week muscle strengthening of major muscle groups in the last three months)
You will not qualify if you...
- Unable or unwilling to receive medical clearance by a physician after screening for major signs or symptoms of cardiovascular diseases, diabetes, or renal disease and safety to exercise
- Using drugs for diabetes management (e.g., exogenous insulin, Ozempic, metformin) or actively losing more than 5 kg in the past 3 months from drugs or other reasons
- Injury or other reason preventing completion of a 30 minute continuous walk or muscle strengthening exercise
- Unable to access an Ontario Lifelabs location for an overnight fasted blood draw
- Do not have a smartphone compatible with the applications required to collect data
- Cannot read and understand the consent form or communicate in English
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Remote Ontario-wide
Toronto, Ontario, Canada
Actively Recruiting
Research Team
A
Amy A Kirkham, PhD
CONTACT
J
Jenna B Gillen, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
5
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