Physical Activity Options to Improve Blood Sugar Control in Postmenopausal Breast Cancer Survivors Using Hormone Therapy

What this Trial Is About

Researchers are studying the effects of different physical activity strategies on blood sugar levels in sedentary breast cancer survivors who are currently on hormone therapies, compared to postmenopausal women without a history of cancer but matched by age and body mass index. The study aims to compare two new physical activity approaches, called dispersed physical activity and physical activity snacks, against no activity and standard exercise sessions, including walking and resistance training. It also explores if these strategies are more acceptable and feasible for cancer survivors and whether the effects differ between those with and without breast cancer and aromatase inhibitor use. Participants will be randomly assigned to perform one of several physical activity interventions a 30-minute walk before breakfast, a 30-minute walk starting 30 minutes after breakfast, three 10-minute walks after each main meal during the day, 2 minutes of walking or marching every 30 minutes for 7.5 waking hours, or a 30-minute session of muscle strengthening exercises starting 30 minutes after breakfast. Each activity is performed at a self-selected pace, with the resistance exercises guided by video. These sessions are designed to test acute effects on glucose control under different timing and intensity conditions. During the study, participants will wear glucose monitors to measure 24-hour blood sugar levels and changes after meals for each activity day, compared to a no-activity baseline. Researchers will also assess participant acceptability and enjoyment of each physical activity strategy. The study includes monitoring of daytime and nighttime glucose, time spent in low or high blood sugar, and glucose variability. Participants will complete these interventions and assessments over multiple days to compare the effects of each physical activity approach, helping to understand which may be more practical and effective for managing glycemic health in this population.

Alternative Physical Activity Strategies for Breast Cancer Survivors