Personalized Brain Stimulation for Treating Auditory Hallucinations in Schizophrenia Using Navigated rTMS

What this Trial Is About

Researchers are evaluating a novel brain stimulation approach using functionally navigated repetitive transcranial magnetic stimulation rTMS targeting the prefrontal cortex PFC in adults with schizophrenia and related disorders. The study aims to modulate abnormal brain activities linked to symptoms like auditory hallucinations by customizing the stimulation location based on individual brain imaging. This method seeks to improve symptom control and cognitive functions such as working memory and sustained attention. Participants receive either active or sham rTMS treatments, with two sessions per treatment visit separated by a 30-minute rest. Treatment occurs over about 6 weeks with up to 22 visits. The stimulation target is identified individually using brain imaging that assesses the connection between the PFC and symptom-related brain areas, aiming to enhance treatment effects. Throughout the study, participants undergo brain imaging fMRI and electroencephalography EEG assessments at baseline, mid-treatment around 2 weeks, and after treatment completion about 4 weeks. Researchers also evaluate symptoms including auditory hallucinations, negative symptoms, depression, delusions, perception, and cognitive insight using standardized rating scales. Safety and symptom changes are closely monitored during the study period.

Alternative Stimulation Mode and Location for Auditory Hallucination Neuromodulation Treatment