Evaluation of Altitude as an Independent Risk Factor for Mortality in Pediatric Acute Respiratory Distress Syndrome Using Oxygenation, Ventilation, and Hospital Structure Data in a Multicenter Observational Study

What this Trial Is About

Researchers are investigating how geographic altitude and the availability of critical care resources affect health outcomes in children with pediatric acute respiratory distress syndrome (PARDS). This multicenter observational study collects data on patient demographics, physiology, and hospital structures from pediatric intensive care units (PICUs) located at various altitudes worldwide. The goal is to identify differences in PARDS management and develop recommendations tailored to diverse healthcare settings. Participants are grouped based on the altitude of the PICU where they receive care: low altitude (0-1500 meters), intermediate altitude (1501-2500 meters), high altitude (2501-3500 meters), and very high altitude (above 3500 meters). No treatments are given as part of the study; instead, the focus is on observing and analyzing existing care practices and patient outcomes across these different altitude groups. Throughout the study, researchers will collect clinical, physiological, and institutional data from children admitted to PICUs requiring mechanical ventilation and diagnosed with PARDS. They will measure key outcomes such as in-hospital mortality up to 90 days, new health issues at discharge, ventilator-free days, and ICU-free days within 28 days. The study aims to provide evidence to improve critical care practices for children with PARDS globally. Participation may last until hospital discharge or up to 90 days after PICU admission.

Altitude and Outcomes in Pediatric ARDS: A Multicenter Study