Actively Recruiting
Alveolar Macrophage Programming Following Endotoxin Exposure
Led by National Jewish Health · Updated on 2025-05-06
25
Participants Needed
1
Research Sites
693 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The histologic hallmarks of lung inflammation include accumulation of inflammatory cells in the airspaces and interstitium, injury to alveolar epithelial and endothelial cells, loss of epithelial-capillary integrity and accumulation of edema fluid in the interstitium and airspaces. Accordingly, for alveolar repair to occur inflammation must be halted, debris and inflammatory cells removed, injured tissue cells replaced, and capillary barrier function re-established. Macrophages are key players in all of these. Here the investigators hypothesize that resident alveolar macrophages and recruited macrophages serve completely different functions, acting independently (i.e. division of labor) yet cooperatively (synergism).
CONDITIONS
Official Title
Alveolar Macrophage Programming Following Endotoxin Exposure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written, informed consent
- Age between 18 and 50 years
You will not qualify if you...
- Current or recent illness within the past 2 weeks
- Presence or prior history of cardiac, pulmonary, or systemic disease
- Bleeding disorder or use of systemic anticoagulants or antiplatelet therapy
- American Society of Anesthesiology (ASA) class 2 or greater
- Immunocompromised state including HIV, immunoglobulin deficiency, or use of systemic immunosuppressants
- Use of inhaled substances including tobacco, marijuana, e-cigarettes, cocaine, methamphetamines, or toxic vapors in the past 3 months or a smoking history greater than 10 pack-years
- Alcohol use disorder or more than 7 drinks per week for women or more than 14 drinks per week for men in the past 3 months
- Allergy or prior adverse reaction to lidocaine, midazolam, or fentanyl
- Abnormal spirometry or electrocardiogram at screening
- Pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Jewish Health
Denver, Colorado, United States, 80206
Actively Recruiting
Research Team
K
Kara Mould
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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