Actively Recruiting
AM vs PM Exercise Training
Led by Michigan State University · Updated on 2025-09-25
79
Participants Needed
1
Research Sites
159 weeks
Total Duration
On this page
Sponsors
M
Michigan State University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The treatment of high blood pressure, or hypertension, is multifaceted and can include pharmacological therapies (i.e., medications) and lifestyle modifications such as physical activity. Chronotherapy, which describes timing of a treatment with the body's daily rhythms, has recently been used with hypertension medications and has been shown to be effective at lowering blood pressure and reducing the risk of cardiovascular disease events. Specifically, taking medications in the evening was shown to be more effective than morning medication routines. Little information is available about the effectiveness of chronotherapy combined with exercise (i.e., planned physical activity) interventions in older adults with hypertension. The purpose of this study is to examine how exercise training performed in the morning and early evening affects blood pressure and other measures of blood vessel health in postmenopausal females with hypertension.
CONDITIONS
Official Title
AM vs PM Exercise Training
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Systolic blood pressure of 130 mmHg or higher without medication, or 120 mmHg or higher with medication, and diastolic blood pressure of 80 mmHg or higher
- Female aged 55 to 80 years
- Postmenopausal status
- Able to walk without help
You will not qualify if you...
- Physically active regularly with at least 150 minutes of moderate or 75 minutes of vigorous aerobic exercise per week
- Diagnosed with chronic lung diseases such as chronic bronchitis, COPD, emphysema, or pulmonary hypertension
- Having cardiometabolic conditions including diabetes, heart failure, peripheral arterial disease, stroke, coronary artery disease, kidney disease, secondary hypertension, chronic venous insufficiency, or recent deep vein thrombosis within 6 months
- Cancer diagnosis within the past 5 years
- Body mass index over 39 kg/m2
- Current smoker or vape user
- Working night shifts
- Uncontrolled thyroid problems
- Two or more falls in the past year
- Anemia diagnosed within 3 months
- Diagnosed with Parkinson's disease
- Dementia diagnosis
- Unstable angina
- Recent acute pulmonary embolism or infarction
- Recent acute myocarditis or pericarditis
- Recent acute aortic dissection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Michigan State University
East Lansing, Michigan, United States, 48824
Actively Recruiting
Research Team
J
Jill Slade, PhD
CONTACT
K
Katharine Currie, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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