Actively Recruiting
AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight
Led by Novo Nordisk A/S · Updated on 2026-05-13
1150
Participants Needed
72
Research Sites
182 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
CONDITIONS
Official Title
AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight
Who Can Participate
Eligibility Criteria
You may qualify if you...
Key
- Male or female (sex at birth).
- Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study.
- History of at least one self-reported unsuccessful dietary effort to lose body weight.
Key
You will not qualify if you...
- HbA1c ≥ 6.5% (48 millimole per mole [mmol/mol]) as measured by the central laboratory at screening.
- History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
- Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 72 locations
1
South Broward Research LLC
Miramar, Florida, United States, 33027
Actively Recruiting
2
Clinical Neuroscience Solution
Orlando, Florida, United States, 32801
Actively Recruiting
3
Hope Clin Res & Wellness
Conyers, Georgia, United States, 30094
Actively Recruiting
4
Endeavor Health
Skokie, Illinois, United States, 60077
Actively Recruiting
5
Midwest Inst For Clin Res
Indianapolis, Indiana, United States, 46260
Actively Recruiting
6
StudyMetrix Research LLC
City of Saint Peters, Missouri, United States, 63303
Actively Recruiting
7
New York Gastroenterology Associates
New York, New York, United States, 10075
Actively Recruiting
8
UNC Eastowne Medical Office
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
9
PharmQuest Life Sciences LLC
Greensboro, North Carolina, United States, 27408
Actively Recruiting
10
Accellacare and KDCILM, LLC
Wilmington, North Carolina, United States, 28401
Actively Recruiting
11
UPA Ctr Weight and Eating Dis
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
12
Clinical Res Collaborative
Cumberland, Rhode Island, United States, 02864
Actively Recruiting
13
Medical Uni of SC Charleston
Charleston, South Carolina, United States, 29425
Actively Recruiting
14
Coastal Carolina Research Ctr
North Charleston, South Carolina, United States, 29405
Actively Recruiting
15
Hillcrest Clinical Research
Simpsonville, South Carolina, United States, 29681-1538
Actively Recruiting
16
Amarillo Medical Specialists
Amarillo, Texas, United States, 79124
Actively Recruiting
17
Velocity Clinical Res-Dallas
Dallas, Texas, United States, 75230-6855
Actively Recruiting
18
Care United Research, LLC
Forney, Texas, United States, 75126
Actively Recruiting
19
Washington Cntr Weight Mgmt
Arlington, Virginia, United States, 22206
Actively Recruiting
20
Health Res of Hampton Roads
Newport News, Virginia, United States, 23606
Actively Recruiting
21
Selma Medical Associates
Winchester, Virginia, United States, 22601-3834
Actively Recruiting
22
Rainier Clin Res Ctr Inc
Renton, Washington, United States, 98057
Actively Recruiting
23
Fundación CESIM
Santa Rosa, La Pampa Province, Argentina, 6300
Actively Recruiting
24
Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli
Buenos Aires, Argentina, C1425AGC
Actively Recruiting
25
Instituto de Investigaciones Clínicas Córdoba
Córdoba, Argentina, 5000
Not Yet Recruiting
26
Sanatorio Esperanza
Esperanza, Santa Fe, Argentina, S3080BQV
Actively Recruiting
27
CIPADI
Godoy Cruz, Argentina, M5501ARP
Not Yet Recruiting
28
Instituto de Investigaciones Clinicas San Nicolás
San Nicolás, Argentina, B2900
Actively Recruiting
29
Sydney Clinical Trials
Campbelltown, New South Wales, Australia, 2560
Actively Recruiting
30
Sydney Cardiometabolic Centre
Liverpool, New South Wales, Australia, 2170
Actively Recruiting
31
Hunter Diabetes Centre
Merewether, New South Wales, Australia, 2291
Actively Recruiting
32
Heart of Australia
Chelmer, Queensland, Australia, 4068
Actively Recruiting
33
HUB - Hôpital Erasme
Brussels, Belgium, 1070
Not Yet Recruiting
34
UZA - UZ Antwerpen - Department of Endocrinology
Edegem, Belgium, 2650
Not Yet Recruiting
35
UZ Gent - Endocrinologie - Diabetologie
Ghent, Belgium, 9000
Actively Recruiting
36
UZ Leuven - Endocrinology
Leuven, Belgium, 3000
Actively Recruiting
37
MECLINAS
Mechelen, Belgium, 2800
Actively Recruiting
38
AZ Delta - Roeselare
Roeselare, Belgium, 8800
Actively Recruiting
39
C-Health Partners
Calgary, Alberta, Canada, T2V 4J2
Not Yet Recruiting
40
Ocean West Research Clinic
Surrey, British Columbia, Canada, V3Z 2N6
Actively Recruiting
41
G.A. Research Associates Ltd.
Moncton, New Brunswick, Canada, E1G 1A7
Actively Recruiting
42
Nova Scotia Hlth Halifax
Halifax, Nova Scotia, Canada, B3H1V7
Actively Recruiting
43
Milestone Research
London, Ontario, Canada, N5W 6A2
Actively Recruiting
44
Sanos Clinic - Vejle
Vejle, Region Syddanmark, Denmark, 7100
Actively Recruiting
45
Sanos Clinic - Gandrup
Gandrup, Denmark, 9362
Actively Recruiting
46
Steno Diabetes Center Nordjylland
Gistrup, Denmark, 9260
Completed
47
Gentofte Hospital - Center for Klinisk Metabolisk Forskning
Hellerup, Denmark, 2900
Not Yet Recruiting
48
Hillerød Endokrinologisk amb. H0652
Hillerød, Denmark, 3400
Not Yet Recruiting
49
Hvidovre Hospital Endokrinologisk forsknings afsnit 159
Hvidovre, Denmark, 2650
Not Yet Recruiting
50
HOPITAL EUROPEEN GEORGES POMPIDOU_Service de nutrition et diabétologie
Paris, France, 75015
Not Yet Recruiting
51
HCL-HOPITAL LYON SUD_Service d'Endocrinologie-Diabète-Nutrition
Pierre-Bénite, France, 69310
Actively Recruiting
52
CHU NANTES - HOPITAL NORD LAENNEC_Service d'Endocrinologie-Diabétologie-Nutrition
Saint-Herblain, France, 44800
Not Yet Recruiting
53
CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE-HOPITAL RANGUEIL-Service de diabétologie et nutrition
Toulouse, France, 31059
Actively Recruiting
54
CENTRE DE RECHERCHE CLINIQUE PORTES DU SUD_Service d'Endocrinologie-Diabétologie-Maladies Métaboliques
Vénissieux, France, 69200
Actively Recruiting
55
Herz- und Diabeteszentrum NRW - Bad Oeynhausen
Bad Oeynhausen, Germany, 32545
Not Yet Recruiting
56
Zentrum für klinische Studien Südbrandenburg GmbH
Elsterwerda, Germany, 04910
Actively Recruiting
57
MVZ im Altstadt-Carree Fulda GmbH - Zentrum für klinische Studien
Fulda, Germany, 36037
Actively Recruiting
58
SMO.MD GmbH - Zentrum für klinische Studien
Magdeburg, Germany, 39120
Not Yet Recruiting
59
Institut für Diabetesforschung Osnabrück
Osnabrück, Germany, 49080
Actively Recruiting
60
Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann
Witten, Germany, 58455
Actively Recruiting
61
Fowey River Practice
Fowey, Cornwall, United Kingdom, PL23 1DT
Not Yet Recruiting
62
The Adam Practice
Poole, Dorset, United Kingdom, BH16 5PW
Not Yet Recruiting
63
Pickering Medical Practice
Pickering, North Yorkshire, United Kingdom, YO18 8BL
Actively Recruiting
64
The Crouch Oak Family Practice
Addlestone, Surrey, United Kingdom, KT15 2BH
Actively Recruiting
65
The Health Centre
Bradford-on-Avon, United Kingdom, BA15 1DQ
Actively Recruiting
66
EMS Healthcare
Cheshire, United Kingdom, CH65 4LE
Actively Recruiting
67
HMC Health - Heston - The Meadows Centre for Health
Hounslow, United Kingdom, TW4 7NJ
Actively Recruiting
68
Kiltearn Medical Centre
Nantwich, United Kingdom, CW5 5NX
Actively Recruiting
69
Knowle House Surgery
Plymouth, United Kingdom, PL5 3JB
Actively Recruiting
70
Clifton Medical Centre
Rotherham, United Kingdom, S65 1DA
Actively Recruiting
71
Staploe Medical Centre
Soham, United Kingdom, CB7 5JD
Actively Recruiting
72
Albany House Medical Centre
Wellingborough, United Kingdom, NN8 4RW
Actively Recruiting
Research Team
N
Novo Nordisk
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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