Actively Recruiting
AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF
Led by Cytokinetics · Updated on 2026-01-12
60
Participants Needed
24
Research Sites
81 weeks
Total Duration
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AI-Summary
What this Trial Is About
This is a Phase 2 dose-finding study in adult participants with symptomatic HFpEF.
CONDITIONS
Official Title
AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females 40 to 85 years of age at screening
- Diagnosed with heart failure with NYHA functional class II or III
- Screening echocardiography showing left ventricular ejection fraction (LVEF) of 60% or higher
- Screening NT-proBNP 300 pg/mL or higher for participants in sinus rhythm
- Screening NT-proBNP 900 pg/mL or higher for participants with atrial fibrillation or flutter
- Body mass index less than 40 kg/m2
- Stable doses of beta-blockers, ACE inhibitors, ARBs, or ARNIs for more than 30 days prior to screening
- Stable dose of glucagon-like peptide-1 (GLP-1) agonist for more than 24 weeks prior to screening with no plans to change dose during the study
You will not qualify if you...
- History or evidence of any other clinically significant disorder, malignancy, active infection, or condition posing risk to safety or study evaluation
- Other protocol-defined inclusion or exclusion criteria apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 24 locations
1
Eastern Shore Research Institute, LLC
Fairhope, Alabama, United States, 36532
Actively Recruiting
2
University of Arizona Sarver Heart Center
Tucson, Arizona, United States, 85724
Actively Recruiting
3
John L. McClellan Memorial Veterans Hospital
Little Rock, Arkansas, United States, 72205
Actively Recruiting
4
BioSolutions Clinical Research Center
Imperial, California, United States, 92251
Actively Recruiting
5
Profound Research LLC
Pasadena, California, United States, 91105
Actively Recruiting
6
University of California, San Francisco - Heart and Vascular Center
San Francisco, California, United States, 94143
Actively Recruiting
7
FOMAT - Comprehensive Cardiovascular Care
Santa Maria, California, United States, 93454
Actively Recruiting
8
Blue Coast Research Center, LLC
Vista, California, United States, 92081
Actively Recruiting
9
New Generation of Medical Research
Hialeah, Florida, United States, 33016
Actively Recruiting
10
Cleveland Clinic Florida
Weston, Florida, United States, 33331
Actively Recruiting
11
Methodist Medical Center of Illinois
Peoria, Illinois, United States, 61636
Actively Recruiting
12
Louisiana Heart Center
Slidell, Louisiana, United States, 70458
Actively Recruiting
13
Massachusetts General Hospital
Boston, Massachusetts, United States, 02214
Actively Recruiting
14
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
15
Washington University Center for Advanced Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
16
Morristown Medical Center
Morristown, New Jersey, United States, 07960
Actively Recruiting
17
NYU Langone Health
New York, New York, United States, 10016
Actively Recruiting
18
The Lindner Center for Research & Education at The Christ Hospital
Cincinnati, Ohio, United States, 45219
Actively Recruiting
19
Oregon Health and Science University
Portland, Oregon, United States, 97239
Actively Recruiting
20
University of Texas Southwestern Medical Center, Dallas
Dallas, Texas, United States, 75390
Actively Recruiting
21
Center for Advanced Heart Failure
Houston, Texas, United States, 77030
Actively Recruiting
22
DelRicht Research
Vienna, Virginia, United States, 22182
Actively Recruiting
23
Swedish Heart & Vascular Institute, Advanced Cardiac Support Program
Seattle, Washington, United States, 98122
Actively Recruiting
24
Froedtert Hospital - Center for Advanced Care
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
C
Cytokinetics MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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