Actively Recruiting
Led by Regina Grazuleviciene · Updated on 2025-11-28
180
Participants Needed
2
Research Sites
126 weeks
Total Duration
R
Regina Grazuleviciene
Lead Sponsor
L
Lithuanian University of Health Sciences
Collaborating Sponsor
Researchers are studying how exposure to ultrafine particulate matter (PM0.1) and noise pollution affects the risk of cardiovascular diseases and metabolic disorders in adults aged 45 to 64 living in Kaunas City. The study combines an observational survey of about 1,000 residents with a clinical trial involving 180 participants who show early signs of metabolic syndrome. The goal is to see if these environmental factors increase health risks and whether lifestyle changes can help reduce them. In the clinical trial, participants are randomly assigned to one of three groups: a control group maintaining their usual habits, a group encouraged to take daily 30-minute brisk walks in green spaces, and a group following a Mediterranean diet with dietary counseling. The interventions last for 7 days, during which physical activity is tracked with wristband sensors, and dietary intake is supervised. Participants visit the clinic twice, on Day 1 and Day 8, for health measurements and blood sample collection. Participants complete health and lifestyle questionnaires, wear wristband sensors to monitor activity, heart rate, and sleep, and undergo clinical assessments including blood pressure, waist circumference, body composition, and blood tests for metabolic and inflammatory markers. Researchers analyze these data to understand the impact of environmental exposure and lifestyle changes on cardiovascular and metabolic health. The study's findings aim to guide public health strategies to reduce disease risks related to pollution and lifestyle.
CONDITIONS
Ambient Air and Noise Effect on Cardiovascular Health Risk and Lifestyle Intervention to Attenuate It (METSGREEN)
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 7 days
Participants are randomly assigned to one of three groups: control group continuing usual routine, a group performing daily 30-minute brisk walks in urban green spaces, or a group following a Mediterranean diet with dietary guidance. Compliance and activity are monitored during this period.
2 clinical assessments (Day 1 and Day 8) at the Family Medicine Clinic
Duration - Up to 3 years
Participants' cardiovascular health and biological markers are assessed over time to observe long-term effects of environmental exposure and lifestyle interventions.
Assessments at baseline and 12 months; biomarker analysis through study completion
Total: 2 locations
1
Vytautas Magnus university, faculty of Natural Sciences, Environmental sciences
Kaunas, Kaunas County, Lithuania, 53361
Not Yet Recruiting
2
Department of Family Medicine, Lithuanian University of Health Sciences
Kaunas, Lithuania, 44248
Actively Recruiting
R
Regina Grazuleviciene, prof.
S
Sandra Andrusaityte, dr.
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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Regina Grazuleviciene, Sandra Andrusaityte, Audrius Dedele...
https://pubmed.ncbi.nlm.nih.gov/41668846