Flexible Ureterorenoscopy for Surveillance of Upper Tract Urothelial Carcinoma-A Pilot Study

What this Trial Is About

Researchers are evaluating the safety and feasibility of performing flexible ureteroscopy under local anesthesia for patients who have undergone kidney-sparing surgery to manage upper tract urothelial carcinoma. This pilot study aims to assess whether this procedure can be successfully done in an outpatient setting, without the need for general anesthesia. The study will focus on the technical success of the procedure and monitor complications and patient experiences to ensure safety and practicality. The intervention involves ambulatory flexible ureterorenoscopy conducted by experienced urologists. Before the procedure, urine samples will be collected and treated for any infections. Local anesthesia will be applied using transurethral lidocaine jelly, and intravenous sedation may be given optionally. The procedure includes examining the bladder and ureter, possibly removing or exchanging ureteric stents, and inspecting the renal pelvis and ureter with a flexible scope. Any suspicious areas may be biopsied. Continuous monitoring of vital signs will occur during the procedure, and it will be stopped immediately if the patient experiences significant discomfort or vital sign changes. Participants will be observed after the procedure in the ambulatory center until their vital signs are stable and they can urinate properly. Data on baseline characteristics, complications, and patient-reported outcomes will be collected. Complications will be tracked for 30 days following the procedure, and serious adverse events will be monitored until resolved or stabilized. The study plans to enroll 10 subjects and carefully document all procedural details and outcomes to evaluate the approach's safety and feasibility.

Ambulatory Flexible URS for UTUC Surveillance