Actively Recruiting
AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance
Led by Duke University · Updated on 2025-08-21
100
Participants Needed
1
Research Sites
124 weeks
Total Duration
On this page
Sponsors
D
Duke University
Lead Sponsor
B
Boehringer Ingelheim
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal is to conduct a cross-sectional, single timepoint study on older adults with early and intermediate AMD, and with subretinal drusenoid deposits (SDD), and those in normal health, establishing an association between dark adaptation and reading performance under dim illumination, both which depend on rod photoreceptors.
CONDITIONS
Official Title
AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Capable and willing to provide consent
- Diagnosed with early, intermediate dry age-related macular degeneration, geographic atrophy, or have healthy macular health as a control
- At least 50 years of age
You will not qualify if you...
- Unable or unwilling to provide consent or unable to read consent
- Under 50 years of age
- Presence of dense cataracts in the study eye(s) affecting visual function tests
- Presence of glaucoma requiring treatment and/or visual field defects
- Previous retinal laser or surgical therapy in the study eye(s)
- Any other ocular condition requiring long-term therapy or surgery during the study
- Significant corneal or media opacities that prevent adequate eye imaging and functional testing
- Diagnosis of nystagmus interfering with testing
- High myopia of -8 Diopters or more severe
- Any physical or mental condition increasing risk or interfering with study procedures as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Duke Eye Center
Durham, North Carolina, United States, 27710
Actively Recruiting
Research Team
E
Eleonora Lad, MD, PhD
CONTACT
A
Alice Ventura
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here