A randomized, double-blind water taste test to evaluate the equivalence of taste between tap water and filtered water in the Taipei metropolis.
Jing-Rong Jhuang, Wen-Chung Lee, Chang-Chuan Chan
https://pubmed.ncbi.nlm.nih.gov/32770131Actively Recruiting
Phase Not Applicable
Age: 25Years +
FEMALE
ID06968871
Effects of the Ameliorated Pap Test on Cervical Cancer Screening Participation: a Multicenter Randomized Controlled Trial
Led by National Taiwan University Hospital · Updated on 2026-03-03
248
Participants Needed
5
Research Sites
104 weeks
Total Duration
On this page
Sponsors
N
National Taiwan University Hospital
Lead Sponsor
N
National Taiwan University Hospital Hsin-Chu Branch
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating a new approach to Pap smear screening to improve cervical cancer screening participation among women aged 25 and above. This multicenter randomized controlled trial applies the peak-end concept by adding a non-painful step at the end of the Pap test. The study is the first to examine whether this modified Pap test can increase participation rates in cervical cancer screening and reduce recalled pain related to the procedure. Participants are randomly assigned to receive either the traditional Pap test or a modified version where, after sample collection, the speculum remains fixed in place for 15 seconds before removal. This additional step is designed to be non-painful and is performed behind a privacy curtain. All operators follow standardized procedures, and the study includes blinding of participants and cytopathologists to group assignments. The trial plans to recruit at least 248 women across multiple centers in the NTUH Healthcare System, with half receiving the modified test. During the study, participants provide written informed consent and undergo interviews to collect health, lifestyle, and psychological information. Measurements include anxiety scores, pain ratings at various time points, and medical history. Researchers will analyze cervical cancer screening participation at 1 and 3 years, along with real-time and recalled pain scores. The study includes careful monitoring and statistical analyses to assess the effect of the intervention on screening uptake and pain perception over time.
CONDITIONS
Brief Title
Ameliorated Pap Tests and Cervical Cancer Screening Participation
Who Can Participate
Age: 25Years +
FEMALE
Eligibility Criteria
You may qualify if you...
- Women aged 25 or above
You will not qualify if you...
- Ongoing menstruation
- Pregnancy
- Incapability of understanding the numeric pain scales
- Any active cancer at study entry (diagnosed or treated within the previous 6 months, recurrent, regionally advanced or metastatic cancer)
- Previous hysterectomy, pelvic surgery, or radiotherapy
- Active vaginal or uterus infection
- Analgesic use within 24 hours
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for screening and enrollment
Screening Procedure
Duration - Single day
Participants receive either the traditional Pap test or the modified Pap test. The Pap test involves specimen collection for cervical cytology with a privacy curtain separating participants from operators. Those in the modified Pap test group experience an additional 15-second step with the speculum in place, which does not affect specimen quality or cause pain.
1 visit (in-person) for the Pap test procedure
Post-Test Assessment
Duration - Up to 3 months after the Pap test
Participants complete pain evaluations immediately and up to 3 months after the Pap test. Information on tobacco use, alcohol consumption, socioeconomic status, medical history, anxiety, and psychological stress is collected through interviews and measurements.
1 visit for immediate pain assessment and follow-up assessments up to 3 months
Long-term Monitoring
Duration - 3 years
Participants are monitored for cervical cancer screening participation over 3 years to assess the impact of the Pap test intervention on screening uptake.
Follow-up contacts or assessments to record screening participation during 3 years
Trial Site Locations
Total: 5 locations
1
National Taiwan University Hospital Yunlin Branch
Douliu, Taiwan
Actively Recruiting
2
National Taiwan University Hospital Hsin-Chu Branch
Hsinchu, Taiwan
Actively Recruiting
3
National Taiwan University Hospital
Taipei, Taiwan, 100
Actively Recruiting
4
National Taiwan University Cancer Center
Taipei, Taiwan
Actively Recruiting
5
National Taiwan University Hospital Beihu Branch
Taipei, Taiwan
Actively Recruiting
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Research Team
C
Chien-Hsieh Chiang, MD, MPH, PhD
Y
Yu-Chung Wu, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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