Actively Recruiting
Surgical Revision of Lower Limb Amputations to Improve Muscle Control, Sensation, and Reverse Muscle Loss
Led by Brigham and Women's Hospital · Updated on 2026-07-09
26
Participants Needed
3
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are studying a new surgical method for patients with lower extremity amputations. This approach aims to improve motor control, restore proprioception, reduce phantom limb pain, and reverse muscle loss in residual limbs. The study focuses on revising above knee and below knee amputations using innovative biological actuators. Participants will undergo a surgical procedure called residual limb revision, which constructs agonist-antagonist myoneural interfaces AMIs in their residual limbs. These biological actuators are designed to enhance muscle and nerve function, with the goal of improving movement control and sensory feedback. The study will also develop a specialized rehabilitation strategy tailored to this surgery. Throughout the study, participants will be monitored for changes in muscle volume, motor activation, sensory perception, proprioception, general health, and any complications. These measures will be collected over a period of one to three years post-surgery to evaluate the effectiveness and durability of the surgical revision and rehabilitation techniques.
CONDITIONS
Brief Title
AMI Construction in Lower Extremity Residual Limbs
Research Team
M
Matthew J Carty, MD
R
Research Coordinators
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