A Novel Approach to Lower Extremity Residual Limb Revision to Augment Volitional Motor Control, Restore Proprioception and Reverse Limb Atrophy

What this Trial Is About

Researchers are investigating a new surgical method to improve the function and sensation of lower extremity residual limbs in adults who have already had above knee (AK) or below knee (BK) amputations. This approach aims to enhance motor control, restore proprioception (awareness of limb position), reduce phantom limb pain, and regenerate lost muscle mass. The study is designed to develop and test this novel technique and its benefits compared to standard amputation revision methods. The treatment involves a surgical procedure called residual limb revision, which constructs agonist-antagonist myoneural interfaces (AMIs) within the residual limb. This procedure is intended to restore musculotendinous proprioceptive abilities and improve motor and sensory function. Participants will undergo this surgery and serve as their own control to measure changes over time, with a focus on both above and below knee residual limb revisions. The study also aims to establish a new postoperative rehabilitation plan tailored to this surgical approach. Participants will be monitored for up to three years, during which researchers will assess changes in limb shape and muscle volume, motor activation of the AMI muscles, proprioception, sensory perception, general health, and any complications. The study includes various assessments to evaluate the success of the surgery in enhancing limb function and sensation. Participants must be adults aged 18 to 65 who have already had a lower extremity amputation and meet specific health and communication criteria.

AMI Construction in Lower Extremity Residual Limbs