Actively Recruiting
AMIC Compared With Microfracture for Focal Articular Cartilage Damage of the Hip
Led by McMaster University · Updated on 2025-09-24
40
Participants Needed
1
Research Sites
198 weeks
Total Duration
On this page
Sponsors
M
McMaster University
Lead Sponsor
G
Geistlich Pharma AG
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a pilot multi-centre RCT of 40 patients (ages 18-55 years, inclusive) undergoing primary hip arthroscopy with a focal articular cartilage defect of the acetabulum to compare the effect of using autologous matrix-induced chondrogenesis (AMIC) in comparison to microfracture on hip function, health-related quality of life, hip pain, cartilage regeneration, health utility, and any adverse events at 2 years. Follow-up will occur at 6 weeks, 6 months, 12 months, 18 months, and 24 months post-surgery.
CONDITIONS
Official Title
AMIC Compared With Microfracture for Focal Articular Cartilage Damage of the Hip
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 18 to 55 years
- Hip pain lasting 6 months or more with no relief from non-operative treatments
- Full-thickness focal articular cartilage defects of the acetabulum confirmed by MRI and arthroscopy (ICRS grade 3 or 4)
- Cartilage lesions measuring between 3 cm2 and 25 cm2 confirmed by MRI and arthroscopy
- Agreement to participate in the study-specific postoperative rehabilitation
- Ability to speak, read, and understand the site language
- Provided informed consent
You will not qualify if you...
- Cartilage defects on the femoral head
- Previous surgery on the study hip
- Traumatic chondral injury of the hip from a single event
- Advanced osteoarthritis (Tonnis grade 3) or other inflammatory joint disease
- Allergy or hypersensitivity to porcine collagen
- Infection at the surgical site
- Hip dysplasia (lateral centre edge angle < 20°)
- Acetabular over coverage such as coxa profunda or coxa protrusion
- Use of immunosuppressive or anti-proliferative medication
- Chronic pain syndromes
- Significant medical conditions requiring help with daily living
- History of pediatric hip disease
- Uncontrolled diabetes
- Contraindications to MRI (e.g., claustrophobia)
- Ongoing legal or workplace claims
- Incarceration
- Pregnancy or breastfeeding
- Likely difficulty maintaining follow-up as judged by investigator
- Other reasons deemed relevant by the investigator for exclusion
AI-Screening
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Trial Site Locations
Total: 1 location
1
McMaster University
Hamilton, Ontario, Canada, L8N3Z5
Actively Recruiting
Research Team
N
Nicole Simunovic, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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