Actively Recruiting

Age: 18Years +
All Genders
ID06659835

Amino Acid Effluent Loss During Continuous Renal Replacement Therapy: An Explorative Non-interventional Pilot Study

Led by Medical University of Vienna · Updated on 2025-05-25

30

Participants Needed

1

Research Sites

13 weeks

Total Duration

On this page

Sponsors

M

Medical University of Vienna

Lead Sponsor

K

Karolinska Institutet

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are studying amino acid loss during continuous renal replacement therapy (CRRT) in intensive care patients to understand how much amino acid is lost over time and how plasma amino acid levels change with and without CRRT. This observational study aims to measure these changes to improve knowledge about nutritional and metabolic effects in such patients. The study includes two groups: 20 intensive care patients undergoing CRRT and 10 intensive care patients not receiving renal replacement therapy. Amino acid concentrations will be measured in the blood, effluent, and urine over the entire treatment period using advanced measurement techniques. Secondary outcomes include monitoring nitrogen balance, blood urea nitrogen, creatinine, albumin, and nutritional and mobility assessments such as indirect calorimetry and muscle strength scoring. Participants will be monitored throughout their ICU stay, with amino acid levels and other metabolic markers measured regularly for up to 30 days. The duration of CRRT, length of ICU and hospital stay, and mortality will also be tracked up to one year. This non-interventional pilot study collects data during routine care without altering treatment, focusing on detailed biochemical and functional evaluations.

CONDITIONS

Brief Title

Amino Acid Loss During Continuous Renal Replacement Therapy

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Postoperative ICU patients
  • Age 18 years or older
  • Patients receiving enteral and/or parenteral nutrition according to internal standards
  • For CRRT group: planned continuous renal replacement therapy of any type
  • For non-CRRT group: no current or recent (within 30 days) renal replacement therapy
  • For non-CRRT group: no chronic kidney disease stage G3-G5
Not Eligible

You will not qualify if you...

  • Preoperative intensive care patients
  • Patients with liver cirrhosis stage 1-3 by Child-Pugh classification
  • Patients with acute liver failure

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Monitoring

Duration - Up to 30 days

Participants are observed during their stay in intensive care with or without continuous renal replacement therapy. Measurements of amino acid concentrations and other nutritional and mobility assessments are collected over the course of treatment.

Multiple visits depending on ICU stay and treatment duration

Long-term Monitoring

Duration - Up to 1 year

Participants are monitored for length of ICU and hospital stay, including mortality outcomes, to assess longer term effects after treatment.

Periodic assessments during hospital stay and follow-up

Trial Site Locations

Total: 1 location

1

Medical University of Vienna

Vienna, State of Vienna, Austria, 1090

Actively Recruiting

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Research Team

S

Sarah Yadavalli, Dr.

A

Arabella Fischer, Dr.

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Published Research Related To This Trial

Amino acid loss and nitrogen balance in critically ill children with acute renal failure: a prospective comparison between classic hemofiltration and hemofiltration with dialysis.

N J Maxvold, W E Smoyer, J R Custer...

https://pubmed.ncbi.nlm.nih.gov/10809299

Copper, selenium, zinc, and thiamine balances during continuous venovenous hemodiafiltration in critically ill patients.

Mette M Berger, Alan Shenkin, Jean-Pierre Revelly...

https://pubmed.ncbi.nlm.nih.gov/15277163

Trace element and vitamin concentrations and losses in critically ill patients treated with continuous venovenous hemofiltration.

D A Story, C Ronco, R Bellomo

https://pubmed.ncbi.nlm.nih.gov/9934919

A supplemental intravenous amino acid infusion sustains a positive protein balance for 24 hours in critically ill patients.

Martin Sundström Rehal, Felix Liebau, Inga Tjäder...

https://pubmed.ncbi.nlm.nih.gov/29212550

Validation of bedside ultrasound to predict lumbar muscle area in the computed tomography in 200 non-critically ill patients: The USVALID prospective study.

Arabella Fischer, Anatol Hertwig, Ricarda Hahn...

https://pubmed.ncbi.nlm.nih.gov/35263692

Muscle mass, strength and functional outcomes in critically ill patients after cardiothoracic surgery: does neuromuscular electrical stimulation help? The Catastim 2 randomized controlled trial.

Arabella Fischer, Matthias Spiegl, Klaus Altmann...

https://pubmed.ncbi.nlm.nih.gov/26825278