Study on Amino Acid Loss and Plasma Levels in Intensive Care Patients Receiving Continuous Renal Replacement Therapy or No Renal Therapy

What this Trial Is About

Researchers are studying amino acid loss during continuous renal replacement therapy CRRT in intensive care patients to understand how much amino acid is lost over time and how plasma amino acid levels change with and without CRRT. This observational study aims to measure these changes to improve knowledge about nutritional and metabolic effects in such patients. The study includes two groups 20 intensive care patients undergoing CRRT and 10 intensive care patients not receiving renal replacement therapy. Amino acid concentrations will be measured in the blood, effluent, and urine over the entire treatment period using advanced measurement techniques. Secondary outcomes include monitoring nitrogen balance, blood urea nitrogen, creatinine, albumin, and nutritional and mobility assessments such as indirect calorimetry and muscle strength scoring. Participants will be monitored throughout their ICU stay, with amino acid levels and other metabolic markers measured regularly for up to 30 days. The duration of CRRT, length of ICU and hospital stay, and mortality will also be tracked up to one year. This non-interventional pilot study collects data during routine care without altering treatment, focusing on detailed biochemical and functional evaluations.

Amino Acid Loss During Continuous Renal Replacement Therapy