Actively Recruiting
4-aminopyridine for Skin Wound Healing
Led by John Elfar · Updated on 2025-09-03
150
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Many patients suffer from chronic non-healing wounds as well as acute wounds. There is a need to develop treatments to accelerate and improve healing of chronic and acute wounds. More research is needed to evaluate the role of 4-aminopyridine (4-AP), a promising new agent with an excellent safety profile, on wound healing. The investigational treatment will be used to evaluate the role of (4-AP) on the treatment of wounds to accelerate wound healing in healthy adults. The purpose of this study is to evaluate the role of 4-AP on the treatment of wounds to accelerate healing. The investigational treatment will be used to test the hypothesis that 4-AP can speed wound healing.
CONDITIONS
Official Title
4-aminopyridine for Skin Wound Healing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Otherwise healthy adults aged 18 to 70 without skin conditions affecting the axilla or upper inner arm
- Able to understand and report on wound healing and sensory or motor changes
- Eligible for standard wound healing without surgical closure
- Able to give written informed consent
- Capable of attending all scheduled follow-up visits safely
You will not qualify if you...
- History of multiple sclerosis, stroke, or other neurological disorders
- Known allergy to AMPYRA4-aminopyridine
- Current use of aminopyridine medications or compounded 4-AP
- Suspected kidney problems based on screening questionnaire
- History of poor follow-up compliance
- Outside the age range of 18 to 70 years
- Unable to provide informed consent
- Known seizure disorder
- Traumatic brain injury
- Unable to communicate or unwilling to complete study requirements
- Currently taking OCT2 inhibitors such as Cimetidine
- Pregnant, breastfeeding, or incarcerated
- Non-English speaking
- Unable or unwilling to provide calibrated wound photographs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Arizona
Tucson, Arizona, United States, 85724
Actively Recruiting
Research Team
A
Andrea Horne
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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