Actively Recruiting
4-Aminopyridine to Treat Skin Burns
Led by John Elfar · Updated on 2026-03-05
200
Participants Needed
1
Research Sites
139 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Many patients suffer from traumatic burns and current treatments do not increase the regenerative potential of either skin grafts or the remaining uninjured skin. There is a need to develop treatments to accelerate and improve healing of burn injuries. More research is needed to evaluate the role of 4-AP, a promising new agent with an excellent safety profile, on wound and burn healing. The investigational treatment will be used to test the hypothesis that 4-AP accelerates burn healing in traumatically burned patients.
CONDITIONS
Official Title
4-Aminopyridine to Treat Skin Burns
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 80 years
- Injured adults with second-degree burns
- Burns involving at least 6 cm2 of skin area
- Acute burns within 7 days of injury
- Cognitive ability to evaluate burn healing and report sensory or motor changes
- Ability to give written informed consent
- Able to attend all scheduled follow-up visits safely
You will not qualify if you...
- History of multiple sclerosis, stroke, or other neurological disorders
- History of hypersensitivity to AMPYRA® or 4-aminopyridine
- Current use of aminopyridine medications including compounded 4-AP
- Suspected kidney problems based on the Choyke questionnaire
- History of poor compliance with follow-up visits
- Outside the age range of 18 to 80 years
- Unable to provide informed consent
- History of seizure disorder
- Presence of traumatic brain injury
- Unable to communicate
- Unwilling to complete study requirements
- Taking organic cation transporter 2 (OCT2) inhibitors like Cimetidine
- Pregnant, breastfeeding, or incarcerated
- Non-English speaking
- Unable or unwilling to take calibrated photographs of wounds
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Arizona
Tucson, Arizona, United States, 85724
Actively Recruiting
Research Team
C
Carly J Deal, MPH
CONTACT
V
Veronica Rangel, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here