Using Expanded Autologous Epidermal Cells to Treat Large Deep Wounds Covering 30% or More of the Body Surface

What this Trial Is About

Researchers are studying autologous epidermal cell transplantation to help repair large, deep wounds caused by severe burns. This approach addresses the challenge of limited normal skin available for grafting in patients with extensive burns. Traditional skin grafting methods require multiple procedures and have limited expansion, leading to longer healing times and increased scarring. This research evaluates a new technique that expands a small piece of a patients own skin cells in the lab to create larger grafts for wound repair, aiming to improve healing and reduce complications. The treatment involves taking small pieces of the patients skin and rapidly growing the epidermal cells in the lab by 1000 to 5000 times over 2 to 3 weeks. These cultured epidermal cell membranes are then combined with expanded or allogeneic dermis grafts to cover large wounds. This method aims to shorten the time for graft integration, increase survival of the grafts, and reduce scarring. It offers a potential solution for patients with limited skin available for traditional grafts, especially those with very large and deep burns. Participants will be patients with wounds covering 30% or more of their body surface area that require at least two weeks to heal. Researchers will evaluate the success of the grafts by measuring the take rate of the cultured epidermal autografts after 4 weeks and monitor for any serious adverse events up to 52 weeks after treatment. The study involves careful monitoring of wound healing, safety, and long-term outcomes to assess this innovative skin repair method. Total participation duration and follow-up details are based on these outcome timelines.

Amplification of Autologous Epidermal Cells to Repair Large Area Deep Wounds