Significant extrahepatic metastasis

Previous treatment with TAS 102

Serious illness other than colorectal cancer or serious medical condition:

1. Other concurrently active malignancies excluding malignancies that are disease free for more than 5 years or carcinoma-in-situ deemed cured by adequate treatment.
2. Known brain metastasis or leptomeningeal metastasis.
3. Active infection (ie, body temperature ≥38°C due to infection).
4. Ascites, pleural effusion or pericardial fluid requiring drainage in last 4 weeks
5. Intestinal obstruction, pulmonary fibrosis, renal failure, liver failure, or cerebrovascular disorder
6. Uncontrolled diabetes.
7. Myocardial infarction within the last 12 months, severe/unstable angina, symptomatic congestive heart failure New York Heart Association (NYHA III/IV)
8. Gastrointestinal hemorrhage.
9. Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness, or hepatitis B or C.
10. Patients with autoimmune disorders or history of organ transplantation who require immunosuppressive therapy.
11. Psychiatric disease that may increase the risk associated with study participation or study drug administration, or may interfere with the interpretation of study results.

Radiofrequency treatment technically not possible (e.g. larger metal implants)

Cardiac pacemakers/ICD

Patient not able for supine positioning (e.g. due to pain)